主讲人简介：

希腊克里特大学医学院分子系统生物学讲席教授、希腊研究与技术基金会(FORTH)杰出成员。欧洲科学院(Academia Europaea)、德国国家科学院(Leopoldina)、欧洲科学与艺术科学院(European Academy of Sciences and Arts)、美国科学促进会(AAAS)等多院院士。获2026年FEBS Datta Medal、2024年希腊Bodossaki基金会卓越奖、2017年德国Helmholtz协会国际学者奖、2007年德国洪堡基金会贝塞尔研究奖等殊荣。欧洲首位、希腊唯一获得三项ERC资助(两项Advanced Investigator Grant、一项Proof of Concept Grant)的科学家。研究聚焦于坏死性细胞死亡的分子机制、神经退行性疾病、细胞代谢与衰老的相互作用、神经系统的感觉传导与整合机制、以及生物医学研究新遗传工具的开发，在Nature、Cell、Nature Cell Biology等期刊发表高影响力论文百余篇(Google Scholar引用超41,000次，h-index 77)，为衰老与神经退行性疾病机制研究作出开创性贡献。

报告摘要：

Ageing is characterized by the progressive decline of cellular and organismal function, often exacerbated by neurodegenerative disorders such as Alzheimer's and Parkinson's diseases. Autophagy, a conserved cellular degradation pathway, plays a pivotal role in maintaining proteostasis, mitochondrial homeostasis, and neuronal integrity, thereby influencing lifespan and disease progression. In this seminar, Prof. Nektarios Tavernarakis will delve into the molecular underpinnings of autophagic processes, drawing from his extensive research using the nematode C. elegans as a model system. Key topics will include the coordination of mitophagy (mitochondrial autophagy) with mitochondrial biogenesis during ageing. He will also discuss nucleophagy's role in preserving nuclear integrity and germline immortality, highlighting recent findings that nuclear lipid droplet deposition serves as an ageing hallmark. Additionally, the interplay between autophagy and necrotic neurodegeneration will be explored.