主讲人简介：

陈玲玲，核糖核酸功能与应用重点实验室主任，中国科学院分子细胞科学卓越创新中心研究员，国家基金委杰青，首届新基石研究员，首届上海杰出人才。担任中国科学院B类先导专项、国家重点研发计划等项目的负责人。受邀担任Cell、Science、Mol Cell等期刊的编委；担任知名国际学术会议的大会主席，包括国际RNA学会、美国冷泉港实验室、冷泉港亚洲、Keystone会议、美国实验生物学会等。受邀百余次在国际知名学术会议以及知名学术机构做主旨报告和特邀报告。

长期从事核糖核酸（RNA）生物学研究，创建并利用新技术体系，发现环形RNA、sno-lncRNA、SPA等RNA家族，在揭示其生成规律、生物学功能以及与人类疾病的关联等方面取得了多项成果，为相关转化应用提供了理论基础。相关成果以通讯作者发表于Cell、Nature、Science等80余篇，共发表论文百余篇，引用>3万次。获国际RNA学会科研中期成就奖、HHMI国际研究学者、FAOBMB卓越研究奖、中国青年科技奖特别奖、中国青年女科学家奖、科学探索奖等学术奖励。“环形RNA生成和功能机制的研究”获国家自然科学奖二等奖（第一完成人）。

报告摘要：

Long noncoding RNAs (lncRNAs) are emerging as new regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Many lncRNAs are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced like mRNAs. By developing methods for genome-wide discovery and characterization of non-polyadenylated RNAs, we have identified several RNA species with unexpected formats. These RNAs are derived from long primary transcripts via unusual RNA processing pathways and are stabilized by different mechanisms, including capping by small nucleolar RNA (snoRNA)–protein (snoRNP) complexes at their ends, and forming circular structures. We have shown that some such RNAs are involved in gene regulation through distinct mechanisms and are also implicated in human diseases. I will discuss our recent findings of underlying mechanisms related to their formation, subcellular localization and function.