主讲人简介：

Ikuro Abe is the professor of Natural Products Chemistry at Graduate School of Pharmaceutical Sciences, The University of Tokyo. He is a member of Faculty of 1000, the American Chemical Society, Royal Society of Chemistry, and American Society of Biochemistry and Molecular Biology. He also serves on the editorial boards of the scientific journals such as Nat. Prod. Rep. etc. His research interests focus on exploring and engineering the natural products biosynthesis. He has authored 200+ scientific publications including Nature, Nature Chemical Biology, Nature communications, J.Am.Chem.Soc, PNAS.

报告摘要：

b-Nicotinamide adenine dinucleotide (b-NAD) is a pivotal metabolite for all living organisms and functions as a diffusible electron acceptor and carrier in the catabolic arms of metabolism. Furthermore,b-NAD is involved in diverse epigenetic, immunological, and stress-associated processes, where it is known to be sacrificially utilized as an ADP-ribosyl donor for protein and DNA modifications, or the generation of cell-signaling molecules. Here, we report the function ofb-NAD in secondary metabolite biosynthetic pathways, in which the nicotinamide dinucleotide framework is heavily decorated and serves as a building block for the assembly of a novel class of natural products. The gatekeeping enzyme of the discovered pathway (SbzP) hereby catalyzes a sophisticated, pyridoxal phosphate (PLP)-dependent (3+2)-annulation reaction betweenb-NAD andS-adenosylmethionine (SAM), generating a 6-azatetrahydroindane scaffold. Members of this novel family ofb-NAD-tailoring enzymes are widely distributed in the bacterial kingdom and encoded in diverse biosynthetic gene clusters. The findings of this work set the stage for the discovery and exploitation ofb-NAD-derived natural products.