细菌耐药新机制解析
发布时间 :2023-03-09  阅读次数 :11947

报告人:白凡

             北京大学生物医学前沿创新中心(BIOPIC)、北京未来基因诊断高精尖创新中心(ICG)、生命科学学院研究员/正教授

报告时间:2023年3月23日,9:30-11:00

报告地点:生物药学楼树华多功能厅

 

报告人简介:

现任北京大学生物医学前沿创新中心(BIOPIC)、北京未来基因诊断高精尖创新中心(ICG)、生命科学学院研究员/正教授。白凡实验室致力于创新和应用单细胞、单分子技术,探索生物医学前沿交叉领域,关注癌症发生、基因突变和转移机制,关注细菌致病和抗生素耐药的分子机制。已在Science (2篇),Nature,Cell (2篇),Cancer Cell,Nature Immunology,Molecular Cell (2篇)等著名学术期刊发表论文100余篇。曾获得中组部“青年海外高层次人才”计划,基金委优秀青年基金(2017)、杰出青年基金(2021)资助。以课题负责人身份多次获得科技部863计划、“精准医学”重点研发计划、科技重大专项资助,获得国家科技进步二等奖,中国细胞生物学学会-青年科学家奖,树兰医学青年奖,中源协和创新突破奖。研究成果获Cell杂志社2019年中国年度论文,获2019年中国临床医学十大进展。

 

报告摘要:

      Liquid-liquid phase separation is emerging as a crucial phenomenon in several fundamental cell processes. A range of eukaryotic systems exhibit liquid condensates. However, their function in bacteria, which, in general, lack membrane-bound compartments, remains less clear. Here, we used high-resolution optical microscopy to observe single bacterial aggresomes, nanostructured intracellular assemblies of proteins, to undercover their role in cell stress. We find that proteins inside aggresomes are mobile and undergo dynamic turnover, consistent with a liquid state. Our observations are in quantitative agreement with phase-separated liquid droplet formation driven by interacting proteins under thermal equilibrium that nucleate following diffusive collisions in the cytoplasm. We have found aggresomes in multiple species of bacteria and show that these emergent, metastable liquid-structured protein assemblies increase bacterial fitness by enabling cells to tolerate environmental stresses.