题 目：Unusual Enzyme Reactions in Natural Product Biosynthesis
报告人：Ikuro Abe 教授 Graduate School of Pharmaceutical Sciences,The University of Tokyo, Japan
Ikuro Abe received his B.S. (1984) and Ph.D. (1989) from The University of Tokyo. After two years postdoctoral research with Professor Guy Ourisson at the CNRS Institut de Chimie des Substances Naturelles, and mostly with Professor Michel Rohmer at the Ecole Nationale Supérieure de Chimie de Mulhouse (1989-1991), he moved to the USA to work with Professor Glenn D. Prestwich at the State University of New York at Stony Brook (1991-1996) and then at The University of Utah (1996-1998). He returned to Japan to join the faculty at University of Shizuoka (1998-2009), and is currently Professor of Natural Products Chemistry at Graduate School of Pharmaceutical Sciences, The University of Tokyo (2009-). His research interests mostly focus on exploring and engineering the natural products biosynthesis. He has authored 200+ scientific publications including Nature, Nature Chemical Biology, Nature Communications, J. Am. Chem. Soc., Angew. Chem. Int. Ed., and Proc. Natl. Acad. Sci. USA. He is currently President of The Japanese Society of Pharmacognosy.
Meroterpenoids are hybrid natural products that are partially derived from terpenoids, and those from fungi exhibit extremely diverse structures and biological activities. Recent progress in the research of fungal meroterpenoid biosynthesis has revealed several unusual enzyme reactions, including post-cyclization modification reactions by oxygenases, such as FAD-dependent monooxygenases, cytochrome P450 monooxygenases, and non-heme iron-dependent dioxygenases. These oxidative processes build molecular complexity and contribute to the structural diversification of fungal meroterpenoids. In this presentation, our most recent structure-function studies of these unique enzymes will be discussed.