Towards Understanding Antiviral Drug Toxicity
发布时间 :2018-05-08  阅读次数 :5391

报告题目Towards Understanding Antiviral Drug Toxicity

主讲人:Whitney Yin

主讲人简介:Associate Professor and Assistant Director, Department of Pharmacology and Toxicology,The University of Texas Medical Branch at Galveston, Homepage:






报告摘要:Mitochondrial DNA and RNA polymerases are targets of antiviral drugs against HIV and HCV (hepatitis C virus), causing drug toxicity. We conducted enzymatic and structural studies to understand the molecular basis for drug toxicity. By comparative structural and functional studies of viral target and human adverse reaction target, we identified key features in the molecules to reduce drug toxicity while maintaining drug efficacy.