报告题目: Mechanical Properties of Human Heart Trabeculae Carneae and its Effects on Diastolic Cardiac Function

报 告  人: 韩海潮（Hai-Chao Han）教授

报告时间: 7月12日（星期三）上午10时

报告地点: 闵行校区生物药学楼 2号楼2-116会议室

联 系  人：齐颖新，Tel: 34204863；email： qiyx@sjtu.edu.cn

摘  要: Trabeculae carneae are considered embryologic remnants that play no functional role in the adult heart. Thickening of the ventricular wall and the trabeculae carneae as well as fibrosis of trabeculae carneae occurs in LV hypertrophy but its role in cardiac function remains unclear. The objectives of our study are to characterize the mechanical properties of trabeculae carneae and determine the contribution of trabeculae carneae to the LV diastolic compliance. Our results demonstrated that trabeculae carneae is softer than the myocardium and cutting trabeculae carneae increases the LV compliance in human hearts. These results suggest that cutting LV trabeculae carneae could be a potential approach to treat patients with diastolic heart failure.

Information about graduate programs and opportunities at UTSA for graduate student exchange will be discussed.

讲演人简介：

韩海潮（Hai-Chao Han）教授，美国德克萨斯大学圣安东尼奥分校（UTSA）机械工程系系主任、Zachry特聘教授(Endowed Chair)。西安交通大学博士（与美国加州大学圣迭戈分校UCSD联合培养）、美国佐治亚理工大学（Georgia Tech）生物医学工程博士后。研究方向：心血管生物力学。现任美国医学与生物工程院会士（AIMBE Fellow）、美国机械工程学会会士（ASME Fellow）、美国心脏学会会士（AHA Fellow），兼任美国ASME J Biomech Eng 副编辑（Associate Editor）和《医用生物力学》编委等。曾获美国NSF Career Award等奖励。

e-mail: hai-chao han@utsa.edu

Short Bio.

Dr. Han is the Zachry Endowed Chair Professor and Department Chair of Mechanical Engineering at the University of Texas at San Antonio (UTSA). He received his Ph.D. degree in Solid Mechanics/Biomechanics in 1991 from Xi’an Jiaotong University in China with joint training from the University of California at San Diego under the tutelage of Professor YC Fung. Dr. Han was an Associate Professor at Xi’an Jiaotong University and a Research Engineer II at Georgia Institute of Technology before joining UTSA in 2003.

Dr. Han’s research interests are in the area of cardiovascular biomechanics with focus on arterial wall mechanical and instability, cardiac mechanics, and tissue remodeling. He has published over 100 peer-reviewed journal papers. He received a CAREER award from NSF in 2007. He is a Fellow of American Heart Association (AHA), College of Fellows of American Institute for Medical and Biological Engineering (AIMBE), and American Society of Mechanical Engineers (ASME). He is an Associate Editor of the ASME Journal of Biomechanical Engineering and a member of editorial boards of a number of journals.