【报告题目】S-layer proteins: general principals and many applications.
【报告人】 Prof. Uwe B.Sleytr
Crystalline bacterial cell surface layer (S-layer) proteins have been optimized during billions of years of biological evolution as constituent elements of bacterial and archaeal cell envelopes. The broad application potential of S-layers in nanobiotechnology is based on the specific intrinsic features of the monomolecular arrays composed of identical protein or glycoprotein subunits. Most important physicochemical properties and functional groups on the protein lattice are arranged in well-defined positions. Many applications of S-layers depend on the capability of isolated subunits to reassemble into monomolecular arrays in suspension or on suitable surfaces (e.g. polymers, metals, silicon wafers) or interfaces (e.g. lipid films, liposomes, emulsomes). S-layers also represent a unique structural basis and patterning element for generating more complex supramolecular structures involving all major classes of biological molecules (e.g. proteins, lipids, glycans, nucleic acids or combinations of that). The biomimetic approach, copying the supramolecular building principle of S-layer-associated plasma membranes developed by archaea, offers manifold application potentials as far as to novel technologies for the generation of functional lipid membranes and biomimetic virus envelopes. Thus, S-layers fulfil key requirements as building blocks and patterning elements for the production of new supramolecular materials and nanoscale devices as required in molecular nanotechnology, nanobiotechnology, synthetic biology, and biomimetics.