报告题目：Nanotechnology for Drug Delivery and Tissue Engineering
报 告 人：Qiaobing Xu 助理教授
Department of Biomedical Engineering,
Tufts University, Medford, MA 02155, USA
联 系 人：夏小霞 021-34207028
Biomaterials at nanoscale have been widely studied as novel vectors for controlled drug delivery and artificial matrices for tissue engineering. In my group, we are interested in developing micro/nanotechnology for biomedical applications, including nanomedicine and tissue engineering. In the first part of my presentation, I will talk about the development of a combinatorial library of lipid-like materials and their applications as non-viral vectors for the intracellular delivery of various biomacromolecules, including DNA, mRNA and proteins for cancer therapy. From the library screening, we attempted to build a correlation between the chemical structures of the delivery vectors and their efficiency in biomacromolecule delivery, which will be useful for the rational design of novel delivery systems. In the second part of my talk, I will present a novel technique, called “Bioskiving” that we recently developed to fabricate novel tissue constructs from decellularized biological tissues. For example, we fabricated various 2D and 3D constructs from a piece of decelullarized tendon which comprises of bundles of well aligned collagen nanofibers using a combination of tissue sectioning, stacking and rolling. We have further extended this strategy to other decellularized tissues. Some potential biomedical applications, such as nerve conduits and blood vessels, of this novel fabrication strategy will be discussed.
Dr. Qiaobing Xu is currently an assistant professor in Department of Biomedical Engineering at Tufts University. He also holds adjunction assistant professor position in Department of Chemical and Biological Engineering and School of Medicine at Tufts University. He obtained his B.S. in 1999, and M.Sc. in 2002 (Advisor: Prof. Xi Zhang) from Department of Chemistry, Jilin University, Changchun, China. He obtained his PhD in chemistry under the guidance of Prof. George Whitesides from Harvard University where he invented “Nanoskiving”, a novel technology to fabricate functional nanomaterials. From 2007-2010, he was a Cancer Center for Nanotechnology Excellence postdoctoral fellow with Prof. Robert Langer at MIT, where he worked on developing novel nanomaterials for drug delivery applications. He joined Tufts in September, 2010. His current research interests lie at the intersection of material science engineering, specifically micro/nanoscience, and biomedical application. His work involves using combinatorial method to develop novel materials for the delivery of therapeutic biomacromolecules and using nanotechnology to develop novel biomaterials for tissue engineering. He received Charlton Award from Tufts University School of Medicine in 2012 and named the Pew Scholar for Biomedical Sciences from Pew Charitable Trusts in 2013.