发布时间 :2014-09-10  阅读次数 :2007

报告题目:Microbial biosynthesis of terminal alkenes and alkynes

报  告 人:张文君 博士,University of California, Berkeley



联  系 人:林双君 This e-mail address is being protected from spambots. You need JavaScript enabled to view it.



Terminal alkene and alkyne are readily derivatized functionalities commonly used in chemical synthesis and bioorthogonal reactions. These functionalities are also found in various natural products, but the biosynthetic mechanisms often remain elusive.  We recently identified and characterized two biosynthetic pathways in microbes leading to the generation of terminal alkene and alkyne respectively.  Particularly, a novel non-heme iron dependent decarboxylase/desaturase was revealed to convert fatty acids to terminal olefins; and fatty terminal olefins could be transformed into terminal alkynes through an unprecedented thio-templated pathway.