Epigenetic Inheritance and Reprogramming During Mammalian Early Development 求真讲坛 第十二期

发布时间 :2019-11-18  阅读次数 :640

讲座时间:2019112010:00-11:30

讲座地点:上海交通大学闵行校区生物药学楼树华报告厅

主 讲 人:清华大学生命科学学院研究员 颉伟

主办单位:生命科学技术学院

人:邢海娜 (xinghaina@sjtu.edu.cn)

 

               

 

主讲人简介:

颉伟教授2003年毕业于北京大学生命科学学院,2008年在UCLA美国科学院院士Michael Grunstein实验室完成了分子生物学的博士以及统计学硕士的双学位学习。之后在 UCSD任兵教授实验室完成了博士后工作。2013年入选中国青年千人计划并加入清华大学生命科学学院任研究员,同时加入清华——北大生命科学联合中心。

颉伟教授自2013年全职来到清华大学工作以来,主要以小鼠和胚胎干细胞为模式系统,应用分子生物学、基因组学和计算生物学,研究配子和早期胚胎细胞命运与发育的调控机制。取得了一系列重要的科研进展,最早在DNA水平阐明哺乳动物生命起始时期染色体动态调控以及组蛋白修饰的世代间遗传问题。共发表高水平论文40余篇,包括以通讯作者在 Nature(4篇),Science(1篇),Nat Genet(2篇),Mol Cell(4篇)等国际重要刊物上发表论文,同时应邀在Trends in Cell Biology和 Nature Reviews撰写综述。由于这些成果,颉伟获得基金委杰出青年基金,香港求是杰出青年学者,谈家桢生命科学创新奖,中源协和生命科学创新奖,树兰医学青年奖,中国青年科技奖等荣誉,并于2017年入选美国霍华德休斯顿研究院的国际学者。

 

内容简介:

Drastic epigenetic reprogramming occurs during mammalian early embryogenesis. Deciphering the molecular events underlying these processes is crucial for understanding how epigenetic information is transmitted between generations and how life really begins. Probing these questions was previously hindered by the scarce experimental materials that are available in early development. By developing a set of ultra-sensitive chromatin analysis technologies, we investigated chromatin reprogramming during early mouse development for chromatin accessibility, histone modifications, and 3D architecture. These studies unveiled highly dynamic and non-canonical chromatin regulation during maternal-to-zygotic transition and zygotic genome activation. Recently, we further showed how the oocyte epigenome is established through extensive cross talks of chromatin modifications, and how its defects exert a profound impact on embryonic development. Finally, I will also discuss how chromatin reprogramming occurs in other species including humans. Comparison among different species reveals both conservation and divergence during evolution in the molecular principles underlying epigenetic inheritance and reprogramming between generations.

 

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