于明

长聘副教授

  • 电话:021-34205623
  • 邮箱:mingyu@sjtu.edu.cn

学术经历

  • 1996 – 2000    学士,微生物学,内蒙古大学生命科学学院 
  • 2000 – 2005    博士,生物化学与分子生物学,北京大学生命科学学院 
  • 2005 – 2007    博士后,Department of Immunobiology, Yale University School of Medicine 
  • 2007 – 2010    博士后,Boston Children’s Hospital,Harvard Medical School 
  • 2010 – 2015    博士后,Laboratory of Biochemistry & Molecular Biology,The Rockefeller University 
  • 2016 – 2022   长聘教轨副教授,上海交通大学生命科学技术学院
  • 2022-              长聘副教授,上海交通大学生命科学技术学院

研究方向

血细胞发育和癌症的转录和表观调控

主要利用基因组学(ChIP-seq、RNA-seq、PRO-seq、CUT&Tag和CLIP-seq等)、CRISPR-Cas9基因编辑、蛋白质组学和小鼠遗传学等技术来阐明转录和表观遗传因子PAF1 complex(Yu et al., Science, 2015)、Super Elongation Complex、MLL1、GATA1(Yu et al., Molecular Cell, 2009)和RUNX1(Yu et al., Molecular Cell, 2012; Yu et al., PNAS, 2008)在生理条件下如何调控血细胞的发育,而与它们相关的失调如何诱发癌症。

代表论著

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    Yang, Z., Zhang, G., Zhao, R., Tian, T., Zhi, J., Wei, G., Roeder, R. G., Jing, L., and Yu, M. (2024) MLL-AF9 regulates transcriptional initiation in mixed lineage leukemic cells, J Biol Chem 300, 107566.

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    Wang, T., Zhao, R., Zhi, J., Liu, Z., Wu, A., Yang, Z., Wang, W., Ni, T., Jing, L., and Yu, M. (2023) Tox4 regulates transcriptional elongation and reinitiation during murine T cell development, Communications Biology 6, 613. doi: 10.1038/ s42003-023-04992-y.

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    Liu, Z., Wu, A., Wu, Z., Wang, T., Pan, Y., Li, B., Zhang, X., and Yu, M. (2022) TOX4 facilitates promoter-proximal pausing and C-terminal domain dephosphorylation of RNA polymerase II in human cells. Commun Biol. Apr 1;5(1):300. doi: 10.1038/s42003-022-03214-1.

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    Wu, A., Zhi, J., Tian, T., Cihan, A., Cevher, M., Liu, Z., David, Y., Muir, T.W., Roeder, R.G., and Yu, M. (2021) DOT1L complex regulates transcriptional initiation in human erythroleukemic cells. Proc Natl Acad Sci U S A 118(27) e2106148118.

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    Pei, T. T., Li, H., Liang, X., Wang, Z. H., Liu, G., Wu, L. L., Kim, H., Xie, Z., Yu, M., Lin, S., Xu, P., and Dong, T. G. (2020) Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system, Nat Commun 11, 1865.

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    Yu, M., Yang, W., Ni, T., Tang, Z., Nakadai, T., Zhu, J., and Roeder, R.G. (2015) RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II. Science 350, 1383-1386. 

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    Wang, E., Kawaoka, S., Yu, M., Shi, J., Ni, T., Yang, W., Zhu, J., Roeder, R. G., and Vakoc, C. R. (2013) Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia, Proc Natl Acad Sci U S A 110, 3901-3906. 

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    Yu, M., Mazor, T., Huang, H., Huang, H. T., Kathrein, K. L., Woo, A. J., Chouinard, C. R., Labadorf, A., Akie, T. E., Moran, T. B., Xie, H., Zacharek, S., Taniuchi, I., Roeder, R. G., Kim, C. F., Zon, L. I., Fraenkel, E., and Cantor, A. B. (2012) Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors, Mol Cell 45, 330-343. 

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    Amigo, J. D., Yu, M., Troadec, M. B., Gwynn, B., Cooney, J. D., Lambert, A. J., Chi, N. C., Weiss, M. J., Peters, L. L., Kaplan, J., Cantor, A. B., and Paw, B. H. (2011) Identification of Distal cis-Regulatory Elements at Mouse Mitoferrin Loci Using Zebrafish Transgenesis, Mol Cell Biol 31, 1344-1356. 

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    Yu, M., Riva, L., Xie, H., Schindler, Y., Moran, T. B., Cheng, Y., Yu, D., Hardison, R., Weiss, M. J., Orkin, S. H., Bernstein, B. E., Fraenkel, E., and Cantor, A. B. (2009) Insights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis, Mol Cell 36, 682-695.