Formation of the human spine: lessons from pluripotent stem cells

发布时间 :2019-04-22  阅读次数 :887

主讲人:Olivier Pourquie

报告时间:424日(周三)下午130-230    

报告地点:上海交通大学闵行校区生命学院1-105

联系人:郭熙志 

 

报告人简介:

Olivier Pourquie教授,现任美国哈佛大学医学院遗传学教授,Brigham和妇女医院病理学教授。毕业于法国巴黎高科农业学院,曾任职Howard Hughes医学研究所研究员。曾任法国遗传、分子与细胞生物学研究所(IGBMC)主任,Development杂志的主编。在CellNatureScience等期刊发表一百余篇论文。他在控制椎骨的时空发育方面的工作被Nature杂志认为是二十世纪发育生物学的最重要的里程碑之一。

 

报告简介:

We are interested in the development of the vertebrate musculo-skeletal axis. Using chicken and mouse embryos as model systems, we combine developmental biology and genomic approaches to study patterning and differentiation of the precursors of muscles and vertebrae. While most of this work has been carried out in vivo, we are now developing protocols to recapitulate these early developmental processes in vitro using mouse and human embryonic or reprogrammed stem cells. We are also turning to translational approaches, using our understanding of the early development to produce cells of the muscle and vertebral lineages in vitro from pluripotent cells to study human diseases of the musculo-skeletal axis and for cell therapy approaches.

 

我们以鸡和小鼠胚胎作为模型,通过发育生物学和基因组方法来研究肌肉和椎骨前体的组织和分化。开发使用小鼠和人胚胎或重编程干细胞技术,在体外重现这些早期发育过程。利用我们对早期发育的理解,从多能干细胞体外产生肌肉和脊椎谱系细胞,研究开发肌肉-骨骼相关人类疾病和细胞治疗方法。

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