Role of Sphingolipid Signaling in Glaucoma
题 目：Role of Sphingolipid Signaling in Glaucoma
报告人：Jie Fan 研究员 Med. Univ. of South Carolina
鞘脂代谢Sphingolipids are a class of lipids containing sphingosine backbone. They were originally identified as major structure components of cell membranes. But they are now recognized as vital regulators of multiple biological processes, including cell growth, differentiation, apoptosis and vascular angiogenesis. In the eye, recent studies have shown that sphingolipid-signaling plays important roles in the homeostasis of photoreceptors and retinal pigment epithelium, and the modulation of conventional outflow resistance. These discoveries support functional roles for sphingolipids in the eye; however, the roles of these molecules in the optic neuropathy associated with ocular hypertensive insult are unknown.
Glaucoma is a disease in which the optic nerve undergoes chronic biomechanical and metabolic insults resulting in axonal injury and eventual retinal ganglion cell death. It is the second leading cause of blindness worldwide. A number of molecular abnormalities typical of an inflammatory state have been described in glaucoma animal models and patients. The goal of this presentation to share our discoveries about the sphingolipid signaling’ s contribution to the optic neuropathy that develops in glaucoma, and to discuss the potential strategies that can prevent or delay the vision loss associated with glaucoma.