报告题目: Photosensory Signaling by the Phytochrome Family
报告人：Professor Peter H. Quail
Professor and Research Director, University of California-Berkeley, 800 Buchanan St Albany, California 94710
Member, National Academy of Sciences-2004
Research Director and Professor, University of California-Berkeley, 1987
Professor, University of Wisconsin, 1984
Associate Professor, University of Wisconsin, 1979
Postdoctor, Universita¨t Freiburg,1971 and Michigan State University, 1968
Ph.D., University of Sydney, Australia, 1968B.S., Agriculture University of Sydney, Australia, 1964
They research molecular mechanisms by which light regulates gene expression in plants, focusing on the phytochromes family of photoreceptors. The photoreceptor molecule acts as a biological switch that upon perception of the light signal, triggers changes in transcription detectable within 5 minutes of stimulus. They recently developed a novel light-switchable gene promoter system potentially usable in any light-accessible eukaryotic cell system for rapid, conditional induction or repression of expression. They have obtained evidence that light-induced activation of the phytochrome molecule induces intranuclear phosphorylation of the bHLH transcription factor, PIF3, preceding its proteosome-mediated degradation. Their studies suggest that phy-induced phosphorylation of target proteins may represent the primary intermolecular signaling transaction of the activated photoreceptor.
Honors and Awards
The Stephen Hales Prize - American Society of Plant Biologists-2008Member - National Academy of Sciences-2004Fellow - American Association for the Advancement of Science -2004
An Institute for Scientific Information award for being among the top 15 most-cited authors in the plant and animal science discipline-2002
A LI-COR Award for Distinguished Contributions to Photochemistry Photobiology -1995
An American Society of Photobiologists Research Award -1988
Franklin, K. A. and P. H. Quail (2010). "Phytochrome functions in Arabidopsis development." J. Exp. Bot., 61:11-14.Leivar, P., J. M. Tepperman, et al. (2009). "Definition of early transcriptional circuitry involved in light-induced reversal of PIF-imposed repression of photomorphogenesis in young Arabidopsis seedlings." Plant Cell 21(11): 3535-3553.Leivar, P. and P. H. Quail (2010). "PIFs: pivotal components in a cellular signaling hub." Trends Plant Sci., In press.Quail, P. H. 2010. Phytochromes. Current Biology, 20: R504-R507.Kikis, E. A., Oka, Y., Hudson, M. E., Nagatani, A., and Quail, P.H. 2009. Residues clustered in the light sensing knot of phytochrome B are necessary for conformer-specific binding to signaling partner PIF3. PLoS Genet 5(1): e1000352.doi:10.1371/journal. pgen.1000352. PMCID: PMC2621353.Leivar, P., Monte, E., Oka, Y., Liu, T., Carle, C., Huq, E. and Quail, P.H. 2008. Multiple phytochrome-interacting bHLH transcription factors repress premature photomorphogenesis during early seedling development in darkness. Current Biol., 18:1815-1823. PMCID: PMC2651225.Leivar, P., Monte, E., Al-Sady, B., Carle, C., Storer, A., Alonso,, J. M., Ecker, J. R., and Quail, P. H. 2008. The Arabidopsis phytochrome-interacting factor PIF7, together with PIF3 and PIF4, regulates responses to prolonged red light by modulating phyB levels. Plant Cell, 20:337-352. PMCID: PMC2276449Al-Sady, B., Kikis, E. A., Monte, E., and Quail, P. H. 2008. Mechanistic duality of transcription factor function in phytochrome signaling. Proc. Natl. Acad. Sci., 105:2232-2237. PMCID: PMC2538903.Khanna, R., Shen, Y., Marion, C.M., Tsuchisaka, A., Theologis, A., Schaefer, E. and Quail, P.H. 2007. The basic helix-loop-helix transcription factor PIF5 acts on ethylene biosynthesis and phytochrome signaling by distinct mechanisms. Plant Cell 19:3915-3929. PMCID: PMC2217642.
Monte, E., Al-Sady, B., Leivar, P. and Quail, P. H. 2007. Out of the dark: how the PIFs are unmasking a dual temporal mechanism of phytochrome signaling. J. Exp. Bot., 58:3125-3133.Al-Sady B, Ni W, Kircher S, Schäfer E, Quail PH (2006). Photoactivated phytochrome induces rapid PIF3 phosphorylation prior to proteasome-mediated degradation. Molecular Cell, 23, 439-446.
Khanna, R., Shen, Y., Toledo-Ortiz, G., Kikis, E., Johannesen, H., Hwang, Y.-S. & Quail, P. H. (2006) Functional Profiling Reveals That Only a Small Number of Phytochrome-Regulated Early-Response Genes in Arabidopsis Are Necessary for Optimal Deetiolation. Plant Cell, 18:2157-2171. doi: 10.1105/tpc.106.042200 .Monte, E., Tepperman, J. M., Al-Sady, B., Kaczorowski, K. A., Alonso, J. M., Ecker, J. R., Li, X., Zhang, Y. & Quail, P. H. (2004) The phytochrome-Interacting transcription factor, PIF3, acts early, selectively, and positively and light-induced chloroplast development. Proc. Natl. Acad. Sci. USA, 101, 16091-16098.Khanna, R., Huq, E., Kikis, E. A., Al-Sady, B., Lanzatella, C. & Quail, P. H. (2004) A Novel Molecular Recognition Motif Necessary for Targeting Photoactivated Phytochrome Signaling to Specific Basic Helix-Loop-Helix Transcription Factors. Plant Cell, 16, 3033-3044.Huq, E., Al-Sady, B., Hudson, M., Kim, C., Apel, K. & Quail, P. H. (2004) PHYTOCHROME-INTERACTING FACTOR 1, a basic helix-loop-helix transcription factor, is a critical regulator of the chlorophyll biosynthetic pathway. Science, 305, 1937-1941.
Monte, Elena; Alonso, Jose M; Ecker, Joseph R; Zhang, Yuelin; Li, Xin; Young, Jeff; Austin-Phillips, Sandra; Quail, Peter H (2003). Isolation and characterization of phyC mutants in Arabidopsis reveals complex crosstalk betTheyen phytochrome signaling pathways. Plant Cell, 15:2497-2501Kaczorowski, K. A.; Quail, P. H.(2003). Arabidopsis PSEUDO-RESPONSE REGULATOR 7 (PRR7) is a signaling intermediate in phytochrome-regulated seedling deetiolation and phasing of the circadian clock. Plant Cell 15: 2654-2665Toledo-Ortiz, G.; Huq, E.; Quail, P. H. (2003). The Arabidopsis basic helix-loop-helix transcription factor family. Plant Cell, 15: 1749-1770.Shimizu-Sato, S., Huq, E., Tepperman, J. M. & Quail, P. H. (2002) A light-switchable gene promoter system. Nat Biotechnol, 20, 1041-4.Quail, P. H. (2002) Phytochrome photosensory signalling networks. Nature Rev. | Mol. Cell Biol., 3, 85-93.
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