【报告题目】How much of the human genome is functional?
【报告人】Philip Green, Professor
Department of Genome Sciences, The University of Washington in Seattle
Abstract: A central focus of genomic biology is to identify all genes, regulatory elements, and other functionally important features in the genome. Estimates of the total fraction of DNA that is under purifying selection are of interest inasmuch as they suggest the magnitude of the experimental effort that will be necessary to elucidate all functional elements. Over the last decade, analyses of mammalian genomes have led to the widely accepted view that at least 5% of the human genome -- 150 megabases -- is functionally constrained (the rest being 'junk'), and some recent estimates have been substantially higher. I will discuss a number of issues related to the notion of 'functional', and present several lines of argument suggesting that the correct value is much lower (100 MB or less).
Dr. Green has worked on computational methods for a variety of types of genome analysis including genetic linkage mapping, physical mapping, sequencing, and evolutionary analysis. His honors include election to the US National Academy of Sciences (2001), Fellow of the AAAS (2005), Gairdner Foundation International Award (2002), and HHMI Investigator (2000-09).
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