S-layerproteins:generalprincipalsandmanyapplications.

发布时间 :2013-05-23  阅读次数 :463

【报告题目】S-layer proteins: general principals and many applications.

【报告人】  Prof. Uwe B.Sleytr

【报告时间】2013年5月25  上午9:30

【报告地点】生命科学技术学院树华多功能厅

【联系人】陶飞, This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

【报告人简介】

奥地利科学院院士、美国纽约科学院院士、欧洲科学与艺术学院院士,奥地利自然资源与应用生命科学大学生物纳米技术中心主任。

【报告内容(摘要)】

Crystalline bacterial cell surface layer (S-layer) proteins have been optimized during billions of years of biological evolution as constituent elements of bacterial and archaeal cell envelopes. The broad application potential of S-layers in nanobiotechnology is based on the specific intrinsic features of the monomolecular arrays composed of identical protein or glycoprotein subunits. Most important physicochemical properties and functional groups on the protein lattice are arranged in well-defined positions. Many applications of S-layers depend on the capability of isolated subunits to reassemble into monomolecular arrays in suspension or on suitable surfaces (e.g. polymers, metals, silicon wafers) or interfaces (e.g. lipid films, liposomes, emulsomes). S-layers also represent a unique structural basis and patterning element for generating more complex supramolecular structures involving all major classes of biological molecules (e.g. proteins, lipids, glycans, nucleic acids or combinations of that). The biomimetic approach, copying the supramolecular building principle of S-layer-associated plasma membranes developed by archaea, offers manifold application potentials as far as to novel technologies for the generation of functional lipid membranes and biomimetic virus envelopes. Thus, S-layers fulfil key requirements as building blocks and patterning elements for the production of new supramolecular materials and nanoscale devices as required in molecular nanotechnology, nanobiotechnology, synthetic biology, and biomimetics.

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