报告题目：Metabolic and molecular approaches to determine the control of skeletal muscle mass by the vitamin D receptor

报 告  人：Prof. Philip James Atherton 诺丁汉大学

报告时间：3月22日 下午13:30

报告地点：闵行校区生物药学楼树华多功能厅

联 系 人：吴娜 This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

 

Abstract：

Vitamin D deficiency is highly prevalent the world over and is common in older age and a number of common non-communicable diseases. Vitamin D deficiency is associated with impaired musculoskeletal function. Nonetheless, while the function of Vitamin D in regulating calcium, phosphorus and bone metabolism are well established, the mechanisms by which vitamin D regulates skeletal muscle is poorly understood. Recently the expression of the vitamin D receptor (VDR) was confirmed in skeletal muscle. Using a battery of in vitro and in vivo pre-clinical approaches, this lecture will detail putative mechanisms by which the VDR exerts its influence upon skeletal muscle mass and metabolism.

 

报告人简介：

Prof. Philip James Atherton is a professor at the School of Medicine in University of Nottingham. His research has focused on the identification of central mechanisms regulating metabolism in human musculoskeletal tissues, and the use of more tractable in vitro cell models. Combining molecular biology, stable isotope methodologies and detailed in vivo human physiology, he has been a key part of a research team that discovered a number of fundamental parameters that govern alterations in musculoskeletal metabolism with age and disease. The current direction of his research team involves combining of detailed clinical molecular physiology with the application of carbon/ deuterium stable isotope methodologies and, more recently, the integration of OMIC (genomic/ metabolomic) techniques to discover predictors of, the mechanistic basis for, and means by which to mitigate musculoskeletal declines in ageing and in disease(s). He has published more than 70 international peer reviewed articles and has acted as a principal or co-investigator in a number of successful grant applications from UK research councils, charities, industry and EU sources.