2007.11-2008.10 不列颠哥伦比亚大学,联合培养博士,导师:Stephen G. Withers教授
2007.03-2007.06 首尔国立大学, 访问学生,导师:Young Je Yoo教授
2003.09-2009.07 吉林大学,生物化学与分子生物学,博士,导师:冯雁教授
1999.09-2003.07 吉林大学,生物科学,学士
研究工作经历
2018.01 -迄今,上海交通大学生命科学技术学院,研究员,博士生导师
2013.01-2017.12上海交通大学生命科学技术学院,副研究员
2009.07-2012.12 上海交通大学生命科学技术学院,讲师
研究方向
体外合成生物学催化体系的构建
酶分子设计与定向进化
酶功能及催化机制解析
体外合成生物学催化体系的构建
酶分子设计与定向进化
酶功能及催化机制解析
研究方向
体外合成生物学催化体系的构建
体外合成生物学催化体系的构建
酶分子设计与定向进化
酶分子设计与定向进化
酶功能及催化机制解析
酶功能及催化机制解析
代表论著
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Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang. Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method. Science Advances, 2019,5(10): eaaw8451.
Fuqiang Ma#, Meng Ting Chung#, Yuan Yao, Robert Nidet, Lap Man Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi*, Guang-Yu Yang*. Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform. Nature Communications, 2018, 9:1030. (#equal contribution)
Zhuang Y#, Yang GY#, Chen X, Liu Q, Zhang X, Deng Z, Feng Y. Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme. Metabolic Engineering. 2017, 42:25-32. (#equal contribution)
Han YB, Chen LQ, Li Z, Tan YM, Feng Y, Yang GY*. Structural insights into the broad substrate specificity of a novel Endo-glycoceramidase I belonging to a new subfamily of GH5 glycosidase. J Biol Chem. 2017, 292(12):4789-4800.
Guang-Yu Yang, Caishun Li, Michael Fischer, Christopher W. Cairo, Yan Feng, Stephen G. Withers. A FRET Probe for Cell-Based Imaging of Ganglioside-Processing Enzyme Activity and High-Throughput Screening. Angewandte Chemie International Edition. 2015, 54(18):5389-5393
Yun-Bin Han, Lie Wu, Jamie R. Rich, Feng-Tao Huang, Stephen G. Withers, Yan Feng, Guang-Yu Yang*. Comprehensive Characterization of Sphingolipid Ceramide N-deacylase for the Synthesis and Fatty Acid Remodeling of Glycosphingolipids. Applied Microbiology and Biotechnology. 2015, 99(16):6715-6726.
FT Huang, YB Han, Y Feng, GY Yang*. A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production. Journal of lipid research. 2015, 56(9):1836-1842.
Guangyu Yang, Jamie R. Rich, Michel Gilbert, Warren W. Wakarchuk, Yan Feng, Stephen G. Withers. Fluorescence Activated Cell Sorting as a General Ultra High-throughput Screening Method for Directed Evolution of Glycosyltransferases. J. Am. Chem. Soc., 2010,132(30):10570-10577.