Yao Qian#, Jinmin Gao#, Ming Chen, Bo Pang, Zhijun Tang, Wei Huang, Wen Liu*. Analysis of siderochelin biosynthesis reveals that a type II polyketide synthase catalyses diketide formation. Nature Synthesis 2025, 4(2), 219–232.

Ling Hu#, Miao Li#, Yueqian Sang#, Chengxin Zhao#, Jiwu Huang, Wei Huang, Yanqing Xue, Lei Liu, Yucheng Gu, Pengchen Ma*, Xiao-Song Xue*, Lifeng Pan*, Wen Liu*. Pseudokinase can catalyse peptide cyclization through thioether crosslinking. Nature Chemistry 2025, doi: 10.1038/s41557-025-01954-1.

Yijiao Xiong, Heng Guo, Wen Liu*. Unveiling the biosynthetic logic of nosiheptide based on reconstitution of its bicyclic thiopeptide scaffold. Journal of the American Chemical Society 2025, 147(18), 15847-15858.

Hongbo Wang#, Yike Zou#, Miao Li#, Zhijun Tang#, Jiabao Wang, Zhenhua Tian, Nina Strassner, Qian Yang, Qingfei Zheng, Yujiao Guo, Wen Liu*, Lifeng Pan*, K. N. Houk*. A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nature Chemistry 2023, 15(2), 177-184.

Zhijun Tang#, Bo Pang#, Chang Liu#, Shengjie Guo, Xudong Qu, Wen Liu*. Formation and loading of a (2S)-2-ethylmalonamyl starter unit in the assembly line of polyketide-nonribosomal peptide hybrid sanglifehrin A. Angewandte Chemie-International Edition 2023, 62(23), e202217090.

Bo Pang#, Rijing Liao#, Zhijun Tang#, Shengjie Guo, Zhuhua Wu, Wen Liu*. Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2'-bipyridine formation. Nature Communications 2021, 12(1), 3124.

Qingfei Zheng#, Shoufeng Wang#, Panpan Duan, Rijing Liao, Dandan Chen, Wen Liu*. An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization. Proceedings of the National Academy of Sciences of the United States of America 2016, 113(50), 14318-14323.

Qunfei Zhao#, Min Wang#, Dongxiao Xu, Qinglin Zhang, Wen Liu*. Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A. Nature 2015, 518(7537), 115-119.

Zhenhua Tian#, Peng Sun#, Yan Yan#, Zhuhua Wu, Qingfei Zheng, Shuaixiang Zhou, Hua Zhang, Futao Yu, Xinying Jia, Dandan Chen, Attila Mándi, Tibor Kurtán, Wen Liu*. An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins. Nature Chemical Biology 2015, 11(4), 259-265.

Qi Zhang, Yuxue Li, Dandan Chen, Yi Yu, Lian Duan, Ben Shen, Wen Liu*. Radical-mediated enzymatic carbon chain fragmentation-recombination. Nature Chemical Biology 2011, 7(3), 154-160.