“永新”青年学者、教授
通过模拟生命极限条件下的环境条件，研究生命在极限条件下的物理变化、结构变化、生理变化、代谢变化及生命过程的限制条件，从而探索生命的边界及地球生物圈的边界，并为探索域外生命提供线索。
基于微生物群落宏基因组分析，通过构建群落水平或种群水平的代谢网络模型，在定性分析的基础上定量计算原位环境变化时的微生物群落代谢网络变化，并定量估算这种代谢变化带来的环境影响。
通过分离培养等手段从现代类早期地球环境中获得现存的类早期极端微生物，通过研究该类极端微生物的形态、生理、代谢等特点及其环境适应机制，反推早期生命形态与早期地球的互作方式，并推演生命-地球的演化历程。
Xiao, X.,*#, Zhao, W.,*#,... Xu, X.,* and Liu, S., * Microbial ecosystems and ecological driving forces in the deepest ocean sediments. Cell, 188(5), 1363-1377 (2025). https://www.cell.com/cell/fulltext/S0092-8674(24)01479-X （共一共通讯）
Zhao, W.,# Wang, J.,# Chen, C.,# Jiang, A., Wang, Y., Hu, A., Qi, Q., Chen, Y., Sui, W., Dong, L., Zhang, Y., & Xiao, X.,* Hadal topography incubates hidden microbial hotspots in the deepest ocean. Cell Host & Microbe 34(8), 1523–1539 (2026). http://doi.org/10.1016/j.chom.2026.06.015. (共同一作)
Zhang, W.-J.,# Hu, A.,# Wu, Z.,# Liu, L.,# Li, C., Wang, Y., Wei, Z., Lu, R., Li, J., He, Y., Zhang, T., Liu, S., Wang, J., Meng, L.,* Xiao, X.,* & Zhao, W.,* Unveiling active microbial processes in Earth’s deepest seawater. Cell Host & Microbe 34(8), 1540–1559 (2026). http://doi.org/10.1016/j.chom.2026.07.001. (共同通讯)
Hu, A.,# Zhao, W.,# Wang, J., Qi, Q., Xiao, X., Jing, H.,*. Microbial communities reveal niche partitioning across the slope and bottom zones of the Challenger Deep. Environmental Microbiology Reports 16(4): e13314 (2024).
https://doi.org/10.1111/1758-2229.13314（共同一作）
Zhao, W.,# Zhong, B.,# Zheng, L., Tan, P., Wang, Y., Leng, H., Souza, N., Liu, Z., Hong, L.,* & Xiao, X.,* Proteome-wide 3D structure prediction provides insights into the ancestral metabolism of ancient archaea and bacteria. Nature Communications 13, 7861 (2022). https://doi.org/10.1038/s41467-022-35523-8. （共同第一作者）
Zhao, W., & Xiao, X.,* Seeking the invisible microbial oases in extreme environments. Cell Host & Microbe 34(8), 1504–1508 (2026). http://doi.org/10.1016/j.chom.2026.07.005. (唯一一作)
Liu, Y., Zhang, Z., Ji, M., Hu, A., Wang, J., Jing, H., Liu, K., Xiao, X.*, Zhao, W.*. Comparison of prokaryotes between Mount Everest and the Mariana Trench. Microbiome 10, 215 (2022). https://doi.org/10.1186/s40168-022-01403-y. （共同通讯作者）
Ye, Y.,# Chen, X., # ...Xiao, X., Zhao, W.,* Hong, L.,* and Liu, Z.* Dynamic entity formed by protein and its hydration water. Physical Review Research, 6(3):033316 (2024). https://doi.org/10.1103/PhysRevResearch.6.033316（共同通讯）
Zhang, K.,# Zhao, W.,# Rodionov, D., Rubinstein, G., Nguyen, D., Tanwee, T., Crosby, J., Bing, R., Kelly, R., Adams, M., Zhang, Y., Genome-Scale Metabolic Model of Caldicellulosiruptor bescii Reveals Optimal Metabolic Engineering Strategies for Bio-based Chemical Production. mSystems. 6(3): e0135120. (2021) 10.1128/mSystems.01351-20. （共同第一作者）
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