黄凯

长聘教轨助理教授

  • 电话:+86-
  • 邮箱:huang_kai@sjtu.edu.cn
  • 地址:上海市东川路800号生物药学2号楼2-123
  • 实验室网址:https://scholar.google.com/citations?user=tPTQ6DkAAAAJ&hl=en
  • 博士生导师。入选 2023 上海海外高层次人才计划。获墨尔本大学“Visiting Scholar Award”奖,境内外学术奖励多次,上海市优秀毕业生荣誉称号等。聚焦心肺血管的力化生转换机制与疾病潜在靶标探究。

学术经历

  • 2023.01 – 至今 上海交通大学生命科学技术学院长聘教轨助理教授
  • 2017.09 – 2022.08 美国加州大学洛杉矶分校(UCLA)医学院麻醉系分子医学科、医学系心脏病学科博士后/研究学者
  • 2016.11 - 2017.01 澳大利亚墨尔本大学Alastair Stewart教授实验室,访问学者

代表论著

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    Ren H, Hu W, Jiang T, Yao Q, Qi Y, Huang K. Mechanical stress induced mitochondrial dysfunction in cardiovascular diseases: Novel mechanisms and therapeutic targets. Biomedicine & Pharmacotherapy. 2024; 174, 116545. (通讯作者). JCR Q1

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    Huang K*, Wu Y*, Zhang Y, Youn JY, Cai H. Combination of folic acid with nifedipine is completely effective in attenuating aortic aneurysm formation as a novel oral medication. Redox Biology. 2022; 58:102521. 中科院一区TOP

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    Huang K*, Narumi T*, Zhang Y, Li Q, Murugesan P, Wu Y, Liu NMJ, Cai H. Targeting miR-192-5p, a downstream effector of NOXs, reverses endothelial dihydrofolate reductase deficiency to attenuate abdominal aortic aneurysm formation. Hypertension. 2021;78(2):282-293. 中科院一区TOP

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    Huang K*, Zhang P*, Zhang Z*, Youn JY*, Wang C, Zhang H, Cai H. Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and viral infections: Efficacies and mechanisms. Pharmacology & Therapeutics. 2021;225:107843. ESI Highly Cited Paper 中科院一区TOP

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    Huang K*, Wang Y*, Siu KL*, Zhang Y, Cai H. Targeting feed-forward signaling of TGFβ/NOX4/DHFR/eNOS uncoupling/TGFβ axis with anti-TGFβ and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics. Redox Biology. 2021;38:101757. 中科院一区TOP

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    Huang K, Bao H, Yan ZQ, Wang L, Zhang P, Yao QP, Shi Q, Chen XH, Wang KX, Shen BR, Qi YX, Jiang ZL. MicroRNA-33 protects against neointimal hyperplasia induced by arterial mechanical stretch in the grafted vein. Cardiovascular Research. 2017, 113(5):488-497. (Cover Article & Editor Choice & Editorial; High impact Cardiovascular Research; Recent Cardiovascular Research highlights from China). 中科院一区TOP

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    Jiang J, Huang K, Xu S, Garcia JGN, Wang C, Cai H. Targeting NOX4 alleviates sepsis-induced acute lung injury via attenuation of redox-sensitive activation of CaMKII/ERK1/2/MLCK and endothelial cell barrier dysfunction. Redox Biology. 2020 ;36:101638. 中科院一区TOP

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    Zhang Y, Murugesan P, Huang K, Cai H. NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets. Nature Reviews Cardiology. 2020 Mar; 17(3):170-194. ESI Highly Cited Paper 中科院一区TOP

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    Qi YX, Yao QP, Huang K, Shi Q, Zhang P, Wang GL, Han Y, Bao H, Wang L, Li HP, Shen BR, Wang Y, Chien S, Jiang ZL. Nuclear envelope proteins modulate proliferation of vascular smooth muscle cells during cyclic stretch application. Proc Natl Acad Sci U S A (PNAS). 2016, 113(19):5293-5298. 中科院一区TOP

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    Youn JY, Middlekauff HR, Reudiseuli I, Huang K, Cai H. Endothelial damage in young adult e-cigarette users. Redox Biology. 58 (2023) 102688. 中科院一区TOP