D. Chen, J. Li, Y. Wu, L. Hong and Y. Liu. Structural dynamics-guided engineering of a riboswitch RNA for evolving c-di-AMP synthases. Sci. Adv. (2025).

D. Chen, Z. Han, X. Liang, and Y. Liu. Engineering a DNA polymerase for modifying large RNA at specific positions. Nat. Chem. (2025).

X.Liang, D. Chen, A. Su, and Y. Liu. Divergent molecular assembly and catalytic mechanisms between bacterial and archaeal RNase P in pre-tRNA cleavage. PNAS (2024) 121: e2407579121.

L. Gao, D. Chen, and Y. Liu. Ligand Response of Guanidine-IV riboswitch at Single-molecule Level. eLife (2024).

Yanyan Xue, Jun Li, Dian Chen, Xizhu Zhao, Liang Hong, and Yu Liu. Observation of structural switch in nascent SAM-VI riboswitch during transcription at single-nucleotide and single-molecule resolution. Nat. Comm. (2023) 14: 2320.

S. Wang, D. Chen, L. Gao, and Y. Liu. Short Oligonucleotides Facilitate Co-transcriptional Labeling of RNA at Specific Positions. JACS (2022).

Stagno, J., Y.Liu, et. al. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature (2017) 541: 242-246.

Y.Liu, E. Holmstrom, et. al. Incorporation of isotopic, fluorescent, and heavy-atom-modified nucleotides into RNAs by position-selective labeling of RNA. Nature Protocols (2018) 13: 987-1005.

Y. Liu, E. Holmstrom, et. al. Synthesis and applications of RNAs with position-selective labeling and mosaic composition. Nature (2015), 522: 368-372.

Related Highlights: A machine to manage modifications, Nature Methods (2015), 12: 598-599.