刘昱

特别研究员/长聘副教授

  • 电话:+86-021
  • 邮箱:liuyu_sjtu@sjtu.edu.cn
  • 本科毕业于北京师范大学,博士毕业于美国Wayne State University,博士后在美国National Institutes of Health。获得国家青年千人称号。目前为课题组组长,博士生导师。

学术经历

  • 北京师范大学化学专业学士,美国韦恩州立大学分析化学博士,美国国立卫生研究院博士后。2016年入选国家青年千人,现任上海交通大学独立课题组组长,博士生导师。主要从事RNA研究,包括开发位点选择性修饰RNA的新方法,追踪RNA的动态结构,以及RNA药物、疫苗。部分研究成果以第一作者或通讯作者发表在Nature,Nature Communications, Nature Protocols, JACS 等国际顶级期刊上。

研究方向

采用包括NMR、停流荧光动力学、smFRET等手段探索非编码R...

RNA动态结构-调控基因表达机制研究

位点选择性修饰RNA

PLOR

RNA天然修饰的功能研究

天然修饰对RNA结构和功能影响

RNA共转录折叠研究

从单分子、单碱基的水平研究SAM-VI型核糖开关RNA的共转录折叠

发展位点选择性修饰RNA的新方法,并将修饰应用于提高RNA...

PLOR

代表论著

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    Y.Liu, E. Holmstrom, et. al. Incorporation of isotopic, fluorescent, and heavy-atom-modified nucleotides into RNAs by position-selective labeling of RNA. Nature Protocols (2018) 13: 987-1005.

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    Stagno, J., Y.Liu, et. al. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature (2017) 541: 242-246.

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    Y. Liu, E. Holmstrom, et. al. Synthesis and applications of RNAs with position-selective labeling and mosaic composition. Nature (2015), 522: 368-372.

    Related Highlights: A machine to manage modifications, Nature Methods (2015), 12: 598-599.

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    X. Fang, et. al., Y. Liu, et. al. An unusual topological structure of the HIV-1 Rev response element. Cell (2013), 155: 594-605.

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    Xiaoyu Zhang, Mengyang Li, and Yu Liu. Optimization and characterization of position-selective labelling of RNA (PLOR) for diverse RNA and DNA sequences. RNA Biology (2020) 17: 1009-1017.

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    Lin Wu, Zhijun Liu, and Yu Liu. Thermal adaptation of structural dynamics and regulatory function of adenine riboswitch. RNA Biology (2021) 18: 2007-2015.

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    Lin Wu, Dian Chen, Jineyu Ding, and Yu Liu. A transient conformation facilitates ligand binding to the adenine riboswitch. iScience (2021) 103512: 1-11.

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    Yanyan Xue and Yu Liu. Incorporation of a FRET Pair into a Riboswitch RNA to Measure Mg2+ Concentration and RNA Conformational Change in Cell. International Journal of Molecular Sciences (2022) 23: 1493.

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    S. Wang, D. Chen, L. Gao, and Y. Liu. Short Oligonucleotides Facilitate Co-transcriptional Labeling of RNA at Specific Positions. JACS (2022).

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    Yanyan Xue, Jun Li, Dian Chen, Xizhu Zhao, Liang Hong, and Yu Liu. Observation of structural switch in nascent SAM-VI riboswitch during transcription at single-nucleotide and single-molecule resolution. Nat. Comm. (2023) 14: 2320.

学生培养

  • 在读学生
  • 毕业学生