Characteristics of niacin skin flushing reaction in Chinese psychiatric patients were revealed through our large-scale niacin skin reaction test, and a molecular diagnostic model of schizophrenia with high specificity and sensitivity was developed. Based on this phenomenon, we will focus on the niacin skin response signal pathway from the perspective of genetics, gene expression, protein expression, metabolite levels, etc., in order to reveal the mechanisms of niacin-blunted phenomenon in schizophrenia patients.
Through a GC/MS-based metabolomics study, we revealed the molecular characteristics of metabolic disturbance in patients with schizophrenia and constructed a well-functioning molecular diagnostic model. At this stage, we will systematically analyze the metabolic characteristics of patients with schizophrenia using proteomics, metabolomics, metagenomics, and bioinformatics analysis methods, focusing on fatty acid metabolism, bile acid metabolism, and intestinal microbial-related metabolism. Our goal is to explore the molecular mechanisms of metabolic abnormalities in patients with schizophrenia and develop reliable molecular markers for clinical diagnosis.
Leukocyte proteomic profiling reveals the redox imbalance-centered molecular pathological features of schizophrenia, in which mitochondrial dysfunction and immune inflammatory response together cause elevated oxidative stress, and the antioxidant system and apoptosis is activated in patients with schizophrenia. The study of cell-free DNA also supports the activation of apoptosis in schizophrenia. Based on this, we will continue to carry out in-depth research on mitotic function, immune inflammation and apoptosis in schizophrenia to reveal the mechanism of oxidative stress involved in the development of schizophrenia, and provide strong support for elucidating the etiology of the disease.
Jiang J, Peng C, Sun L, Li J, Hu X, Qing Y, Yang X, Li Y, Xu C, Zhang J, Min J, Li X, Qin S, Mei L, Tan L, Wan C. Leukocyte Proteomic Profiling in First-Episode Schizophrenia Patients: Does Oxidative Stress Play Central Roles in the Pathophysiology Network of Schizophrenia? Antioxidant Redox Signaling. 2019 Sep 10;31(8):579-588.
Xu C, Yang X, Sun L, Yang T, Cai C, Wang P, Jiang J, Qing Y, Hu X, Wang D, Wang P, Cui G, Zhang J, Li Y, Ji F, Liu C, and Wan C. An investigation of calcium-independent phospholipase A2 (iPLA2) and cytosolic phospholipase A2 (cPLA2) in schizophrenia, Psychiatry Research. 2019 Jan 29; 273: 782-87.
Jiang J, Chen X, Sun L, Qing Y, Yang X, Hu X, Yang C, Xu T, Wang J, Wang P, He L, Dong C, Wan C. Analysis of the concentrations and size distributions of cell-free DNA in schizophrenia using fluorescence correlation spectroscopy. Translational Psychiatry. 2018 May 22;8(1):104.
Sun L, Yang X, Jiang J, Hu X, Qing Y, Wang D, Yang T, Yang C, Zhang J, Yang P, Wang P, Cai C, Wang J, He L, Wan C. Identification of the niacin-blunted subgroup of schizophrenia patients from mood disorders and healthy individuals in Chinese population. Schizophrenia Bulletin. 2017 Oct 25; 44(4):896-907.
Hu X, Du S, Yu J, Yang X, Yang C, Zhou D, Wang Q, Qin S, Yan X, He L, Han D, Wan C. Common housekeeping proteins are upregulated in colorectal adenocarcinoma and hepatocellular carcinoma, making the total protein a better "housekeeper". Oncotarget. 2016 Aug 20; doi: 10.18632.
Qing Y, Sun L, Yang C, Jiang J, Yang X, Hu X, Cui D, Xu Y, He L, Han D, Wan C. Dysregulated 14-3-3 family in peripheral blood leukocytes of patients with schizophrenia. Scientific Reports. 2016 Mar 31; 6:23791.
Sun L, Qing Y, Yang X, Yang C, Jiang J, Hu X, Ding J, He L, Tan L, Wan C. Gene expression profiling of the xMHC region reveals 9 candidate genes in schizophrenia. The Journal of Clinical Psychiatry. 2016 May 77; e597-599.
Yang J, Chen T, Sun L, Zhao Z, Qi X, Zhou K, Cao Y, Wang X, Qiu Y, Su M, Zhao A, Wang P, Yang P, Wu J, Feng G, He L, Jia W, Wan, C. Potential metabolite markers of schizophrenia. Molecular Psychiatry. 2013 Jan; 18(1): 67~78.
Zhou K, Yang Y, Gao L, He G, Li W, Tang K, Ji B, Zhang M, Li Y, Yang J, Sun L, Zhao Z, Zhu H, He L, Wan C. NMDA Receptor Hypofunction Induces Dysfunctions of Energy Metabolism And Semaphorin Signaling in Rats: A Synaptic Proteome Study. Schizophrenia Bulletin. 2012 May; 38(3): 579-591.