副研究员
中医典籍《黄帝内经》记载了“怒伤肝、喜伤心、忧伤肺、思伤脾、恐伤肾”，但未阐明其机制。故本人从分子遗传学角度来研究心理活动与躯体疾病相互作用的分子机制：通过生化与细胞分析方法和开发小鼠等模式哺乳动物的行为学研究工具，评价药物对组织器官的损伤及对精神行为的影响，以期发现重要的神经环路，信号通路和关键基因，最终为开发类似安慰剂的药物打下理论和实验基础。
高通量测序及芯片检测产生了海量的遗传信息数据，其中包括基因组、转录组和表观遗传组等。利用不同整合方法进行多组学的研究来揭示基因组与表型组之间的联系，建立多层次的分子扰动谱图，同时开发与特定表型密切相关基因的新检测方法和手段。
1. Cai L, He L. Placebo effects and the molecular biological components involved. Gen Psychiatr. 2019; 32(5): e100089.
2. Cai L, Huang T, Su J, Zhang X, Chen W, Zhang F, He L, Chou KC. Implications of Newly Identified Brain eQTL Genes and Their Interactors in Schizophrenia. Mol Ther Nucleic Acids. 2018; 12: 433-442.
3. Cai L, Zheng LA, He L. The forty years of medical genetics in China. J Genet Genomics. 2018; 45(11): 569-582.
4. Yu H, Yan H, Li J, Li Z, Zhang X, Ma Y, Mei L, Liu C, Cai L, Wang Q, Zhang F, Iwata N, Ikeda M, Wang L, Lu T; Chinese Schizophrenia Collaboration Group, Li M, Xu H, Wu X, Liu B, Yang J, Li K, Lv L, Ma X, Wang C, Li L, Yang F, Jiang T, Shi Y, Li T, Zhang D, Yue W. Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population. Mol Psychiatry. 2017; 22(7): 954-960.
5. Wang MY, Yang XM, Zhang P, Cai L, Yang XB, Chen YW, Jing YY, Kong JL, Yang XW, Sun FL. Sustained Delivery Growth Factors with Polyethyleneimine-Modified Nanoparticles Promote Embryonic Stem Cells Differentiation and Liver Regeneration. Adv. Sci. 2016, 1500393. doi: 10.1002/advs.201500393.
6. Cai L, Chen T, Yang J, Zhou K, Yan X, Chen W, Sun L, Li L, Qin S, Wang P, Yang P, Cui D, Burmeister M, He L, Jia W, Wan C. Serum trace element differences between Schizophrenia patients and controls in the Han Chinese population. Sci Rep. 2015; 5: 15013. doi: 10.1038/srep15013.
7. Cai L, Deng SL , Liang L, Pan H, Zhou J, Wang MY, Yue J, Wan CL, He G, He L. Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population (2013). Human Genetics. 132:265-273.
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