Xiang Yu

Tenure-track Associate Professor

  • Tel: 021-34205134
  • Email: yuxiang2021@sjtu.edu.cn
  • Address: https://www.researchgate.net/profile/Xiang-Yu-29
  • Group leader. Our team focuses on studying the molecular mechanism of RNA biology, including RNA modification and RNA decay, using molecular biology and bioinformatics. Our representative work have been published in Nature Communications, Developmental Cell、 Plant Cell and Genome Research.

Education and Research Experience

  • Aug 2014-Jan 2021: Department of Biology, University of Pennsylvania 

  • Sep 2008-Jun 2014: Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Genetics

  • Sep 2004-Jun 2008: South China Agricultural University, Biotechnology

Selected Publications

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    Wu, Y., Shao, W., Yan, M., Wang, Y., Li, X., Gregory, B.D.,  Yang, J.*, Wang, H.* and  Yu X.* (2024). Transfer learning enables identification of multiple types of RNA modifications using nanopore direct RNA sequencing. Nature Communications 15, 4049 (2024).

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    Yu, X., Willmann, M.R., Vandivier, L.E., Trefely, S., Kramer, M.C., Shapiro, J., Guo, R., Lyons, E., Snyder, N.W., and Gregory, B.D*. (2021). Messenger RNA 5′ NAD+ Capping Is a Dynamic Regulatory Epitranscriptome Mark That Is Required for Proper Response to Abscisic Acid in Arabidopsis. Developmental Cell 56, 125-140.

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    Yu, X.#, Willmann, M.R.#, Anderson, S.J., and Gregory, B.D. * (2016). Genome-Wide Mapping of Uncapped and Cleaved Transcripts Reveals a Role for the Nuclear mRNA Cap-Binding Complex in Cotranslational RNA Decay in Arabidopsis. Plant Cell 28, 2385–2397

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    Yu, X. #, Davenport, J.W. #, Urtishak, K.A., Carillo, M.L., Gosai, S.J., Kolaris, C.P., Byl, J.A.W., Rappaport, E.F., Osheroff, N., Gregory, B.D.*, Felix, A.C.* (2017). Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci. Genome Research 27, 1238–1249.

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    Zhang, Y.#, Xu, P.#, Xue, W.#, Zhu, W.*, Yu, X.* (2023). Diurnal gene oscillations modulated by RNA metabolism in tomato. The Plant Journal. tpj.16400. 

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    Xu, P.#, Zhang, W.#, Wang, X., Zhu, Y., Liang, W., He, Y.*, Yu, X.* (2023). Multiomics analysis reveals a link between Brassica‐specific miR1885 and rapeseed tolerance to low temperature. Plant Cell & Environment. pce.14690. 

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    Yu, X., Wang, H., Lu, Y., de Ruiter, M., Cariaso, M., Prins, M., van Tunen, A., and He, Y. * (2012). Identification of conserved and novel microRNAs that are responsive to heat stress in Brassica rapa. Journal of Experimental Botany 63, 1025–1038.

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    Yu, X. #, Sharma, B. #, and Gregory, B.D.* (2020). The impact of epitranscriptomic marks on post-transcriptional regulation in plants. Briefings in Functional Genomics elaa021.

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    Li, X., Wang, H., Yu, X., Saha, G., Kalafati, L., Ioannidis, C., Mitroulis, I., Netea, M., Chavakis, T. & Hajishengallis, G. (2022). Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. Cell, 185, 1709-1727.

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    Xiao, J., Jin, R., Yu, X., Shen, M., Wagner, J.D., Pai, A., Song, C., Zhuang, M., Klasfeld, S., He, C., et al. (2017). Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis. Nature Genetics 49, 1546–1552.

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