Dan Li

  • Tel: +86-021
  • Email: lidan2017@sjtu.edu.cn
  • Address: Small White Building, Room 206, Xuhui campus

Education and Research Experience

  • Dr. Li joined the Bio-X Institutes at Shanghai Jiao Tong University as a principle investigator in 2017.
  • She received her Ph.D. at the Peking University, followed by working at the University of California, Los Angeles, with Dr. David Eisenberg as a postdoctoral fellow.

Research Interests

Molecular mechanism of protein phase separation and amyloid aggregation

Molecular mechanism of protein phase separation and amyloid aggregation

Protein homeostasis in aging and neurodegenerative diseases

Protein homeostasis in aging and neurodegenerative diseases

Selected Publications

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    Tao Y.Q., Sun Y.P., Lv S.R., Xia W.C., Zhao K., Xu Q.H., Zhao Q.Y., He L., Wang Y., Liu C.*, Li D.* Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology. Nat Commun. 2022 Jul 22;13(1):4226. 

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    Long H.F., Zhang S.N., Zeng S.Y., Tong Y.L., Liu J., Liu C.*, Li D.* Interaction of RAGE with α-synuclein fibrils mediates inflammatory response of microglia. Cell Rep, 2022 Sep 20;40(12):111401 

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    Li D*, Liu C*. Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases. Nat Rev Neurosci. 2022 Sep;23(9):523-534. 

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    Fan Y, Zhao Q, Xia W, Tao Y, Yu W, Chen M, Liu Y, Zhao J, Shen Y, Sun Y, Si C, Zhang S, Zhang Y, Li W, Liu C, Wang J*, Li D*. Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders. Cell Res. 2022 Jun;32(6):585-588. 

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    Dan Li and Cong Liu, Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Nature Chemical Biology, 2021, Jan 11.

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    Yunpeng Sun#, Kun Zhao#, Wencheng Xia, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Cong Liu*, Dan Li* The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, Nature Communications, 2020, Dec 11.

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    Jinge Gu , Zhenying Liu , Shengnan Zhang , Yichen Li , Wencheng Xia , Chen Wang , Huaijiang Xiang , Zhijun Liu , Li Tan , Yanshan Fang , Cong Liu* , Dan Li*,  Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, PNAS, 2020, Dec 8.

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    Zhao, K., Li, Y., Liu, Z., Long, H., Zhao, C., Luo, F., Sun, Y., Tao, Y., Su, X.-D., Li, D.#, Li, X.#, Liu, C.#, Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure. Nature Communications, 2020 , May 26.

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    Gui, X., Luo, F., Li, YC, Zhou, H., Qin,Z., Liu, ZY, Gu, JG, Xie, MY, Zhao, K., Dai, B., Shin, WS, He, JH, He, L., Jiang, L., Zhao, ML, Sun, B., Li, XM, Liu, C.#, Li, D.# Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Nature Communications, 2019 May 1;10(1):2006.

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    Li, D.#, Liu, C.#. Better together: a hybrid amyloid signals necroptosis. Cell 2018 Volume 173, Issue 5, p1068–1070, 17 May.