Hu Zehan

Tenure-track Associate Professor

  • Tel: +86-021
  • Email: zehan.hu@sjtu.edu.cn
  • Address:

Selected Publications

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    Hu Z*#, Zhang C*, Sifuentes-Dominguez L, Zarek CM, Propheter DC, Kuang Z, Wang Y, Pendse M, Ruhn KA, Hassell B, Behrendt CL, Zhang B, Raj P, Harris-Tryon TA, Reese TA#, Hooper LV#. Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection. Science. 2021, 374(6568):eabe6723. (#co-corresponding author)

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    Bang Y-J, Hu Z, Li Y, Gattu S, Ruhn KA, Herz J, Hooper LV#. Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity. Science. 2021, 373(6561):eabf9232.

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    Hu Z*#, Bang YJ*, Ruhn KA, Hooper LV#. Molecular basis for retinol binding by serum amyloid A during infection. Proc Natl Acad Sci U S A. 2019, 116(38):19077-19082. (#co-corresponding author)​

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    Hu Z*, Zhou Q*, Zhang C*, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF#, Chai J#. Structural and biochemical basis for induced self-propagation of NLRC4. Science. 2015, 350(6259):399-404. (*co-first author)

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    Hu Z, Yan C, Liu P, Huang Z, Ma R, Zhang C, Wang R, Zhang Y, Martinon F, Miao D, Deng H, Wang J, Chang J, Chai J#. Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science. 2013, 341(6142): 172-175.

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    Yang X*, Yang F*, Wang W*, Lin G*, Hu Z*, Han Z, Qi Y, Zhang L, Wang J, Sui SF#, Chai J#. Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Research. 2018, 28(1): 35-47. (*co-first author)

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    Liu P*, Hu Z*, Zhou B, Liu S, Chai J#. Crystal structure of an LRR protein with two solenoids. Cell Research. 2013, 23(2): 303-305. (*co-first author)

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    Hu Z#, Chai J#. Structural mechanisms in NLR inflammasome assembly and signaling. Curr. Top. Microbiol. Immunol. 2016; 397:23-42. (#co-corresponding author)

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    Ma R, Han Z, Hu Z, Lin G, Gong X, Zhang H, Nasrallah JB, Chai J#. Structural basis for specific self-incompatibility response in Brassica. Cell Research. 2016, 26(12):1320-1329.

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    Sun Y*, Li L*, Macho AP, Han Z#, Hu Z, Zipfel C, Zhou JM#, Chai J#. Structural basis for flg22-induced activation of the Arabidopsis FLS2-BAK1 immune complex. Science. 2013, 342(6158):624-628.