Tenure-track Associate Professor
Hu Z*#, Zhang C*, Sifuentes-Dominguez L, Zarek CM, Propheter DC, Kuang Z, Wang Y, Pendse M, Ruhn KA, Hassell B, Behrendt CL, Zhang B, Raj P, Harris-Tryon TA, Reese TA#, Hooper LV#. Small proline-rich protein 2A is a gut bactericidal protein deployed during helminth infection. Science. 2021, 374(6568):eabe6723. (#co-corresponding author)
Bang Y-J, Hu Z, Li Y, Gattu S, Ruhn KA, Herz J, Hooper LV#. Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity. Science. 2021, 373(6561):eabf9232.
Hu Z*#, Bang YJ*, Ruhn KA, Hooper LV#. Molecular basis for retinol binding by serum amyloid A during infection. Proc Natl Acad Sci U S A. 2019, 116(38):19077-19082. (#co-corresponding author)
Hu Z*, Zhou Q*, Zhang C*, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF#, Chai J#. Structural and biochemical basis for induced self-propagation of NLRC4. Science. 2015, 350(6259):399-404. (*co-first author)
Hu Z#, Chai J#. Assembly and Architecture of NLR Resistosomes and Inflammasomes. Annual Review of Biophysics. 2023, 52:8.1-8.22. (#co-corresponding author)
Zhang C, Hu Z, Lone AG, Artami M, Edwards M, Zouboulis CC, Stein M, Harris-Tryon TA. Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption. eLife. 2022, 11:e76729.
Yang X*, Yang F*, Wang W*, Lin G*, Hu Z*, Han Z, Qi Y, Zhang L, Wang J, Sui SF#, Chai J#. Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Research. 2018, 28(1): 35-47. (*co-first author)
Liu P*, Hu Z*, Zhou B, Liu S, Chai J#. Crystal structure of an LRR protein with two solenoids. Cell Research. 2013, 23(2): 303-305. (*co-first author)