Yawen He

  • Tel: +86-13564385795
  • Email: yawenhe@sjtu.edu.cn
  • Address: Dongchuan Road #800, Biology and Pharmacy Building 4D-303
  • Ya-Wen He received his BSc in Biology from Central China Normal University in 1992. He obtained his Ph.D. from National University of Singapore in 2006. He then worked as a research fellow at the Institute of Molecular and Cell Biology. In 2010, he joined Shanghai Jiao Tong University as a principal investigator.
DOWNLOAD CV

Education and Research Experience

  • March 2007, Ph.D., National University of Singapore, Molecular Microbiology
  • March 2000, M.Sc., National University of Singapore, Plant Science
  • July 1995, M.Sc., South China Institute of Botany, CAS, Plant Physiology
  • July 1992, B.Sc., Central China Normal University, Biology

Research Interests

Microbial quorum sensing

(1) QS in the phytopathogen Xanthomonas

(2) QS in the human pathogen Pseudomonas aeruginosa

Synthetic biology

(1) Synthetic biology for biopesticides and biostimulants

(2) Synthetic biology for Xanthomonas-derived metabolites such as Xanthan gum, DSF and cumarin

Selected Publications

  • •  

    He Ya-Wen*,#, Jin Z-J*, Cui Y, Song K, Chen B, Zhou L. RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201. mLife. 2024; 3: 74–86.

    PDF SUPP INOF
    •  

    He Ya-Wen*,#, Deng Y*, Miao Y*, Chatterjee S, Tran TM, Tian J, Lindow S. DSF-family quorum sensing signal-mediated intraspecies, interspecies, and inter-kingdom communication. Trends in Microbiology, 2023 Jan;31(1):36-50.

    PDF SUPP INOF
    •  

    Song K, Chen B, Cui Y, Zhou L, Chan KG, Zhang HY, He Ya-Wen. The Plant Defense Signal Salicylic Acid Activates the RpfB-Dependent Quorum Sensing Signal Turnover via Altering the Culture and Cytoplasmic pH in the Phytopathogen Xanthomonas campestris. mBio. 2022,13(2): e0364421. 

    PDF SUPP INOF
    •  

    Chen B, Li RF, Zhou L, Qiu JH, Song K, Tang JL, He Ya-Wen. The phytopathogen Xanthomonas campestris utilizes the divergently transcribed pobA/pobR locus for 4-hydroxybenzoic acid recognition and degradation to promote virulence. Molecular Microbiology. 2020, 114(5): 870-886.

    PDF SUPP INOF
    •  

    Jin ZJ, Zhou L, Sun S, Cui Y, Song K, Zhang X, He Ya-Wen. Identification of a Strong Quorum Sensing- and Thermo-Regulated Promoter for the Biosynthesis of a New Metabolite Pesticide Phenazine-1-carboxamide in Pseudomonas strain PA1201. ACS Synthetic Biology. 2020 Jul 17;9(7):1802-1812.

    PDF SUPP INOF
  • •  

    Cao, XQ, Zhou L, Chen B, He Ya-Wen. Biosynthesis of Xanthomonas yellow pigment xanthomonadins involves an ATP-dependent 3- HBA:ACP ligase and an unusual type II polyketide synthesis pathway. Molecular Microbiology. 2018, Oct; 110(1):16-32.

    PDF SUPP INOF
    •  

    Zhou L, Zhang LH, Cámara M, He Ya-Wen. The DSF Family of Quorum Sensing Signals: Diversity, Biosynthesis, and Turnover in Xanthomonas. Trends in Microbiology. 2017, 25(4):293-303.

    PDF SUPP INOF
    •  

    Zhou Lian*, Wang Xing-Yu*, Sun Shuang, Yang Li-Chao, Jiang Bo-Le, He Ya-Wen. Identification and Characterization of Naturally Occurring DSF-Family Quorum Sensing Signal Turnover System in the Phytopathogen Xanthomonas. Environmental Microbiology, 2015, 17(11):4646–4658.

    PDF SUPP INOF
    •  

    Jin Kaiming*, Zhou Lian*, Jiang Haixia, Sun Shuang, Fang Yunling, Liu Jianhua, Zhang Xuehong, He Ya-Wen. Engineering the central biosynthetic and secondary metabolic pathways of Pseudomonas aeruginosa strain PA1201 to improve phenazine-1-carboxylic acid production. Metabolic Engineering, 2015, 32:30-38.

    PDF SUPP INOF
    •  

    Song K, Li RF, Cui Ying, Chen Bo, Zhou Lian, Han WY, Jiang BL#, and He Ya-Wen#. The phytopathogen Xanthomonas campestris senses and effluxes salicylic acid via a sensor HepR and an RND family efflux pump to promote virulence in host plants. mLife. 2024 Sep 16;3(3):430-444.

    PDF SUPP INOF