Yan Feng

Distinguished Professor

  • Tel: +86-021-34207189
  • Email: yfeng2009@sjtu.edu.cn

Selected Publications

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    Cui L., Wei X., Wang X., Bai L., Lin S., Feng Y*. A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008. ACS Synth Biol., 2020, 294-303. 

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    Deng X., Chen L., Hei M., Tian G., Feng Y*., Yang G*. Structure-guided reshaping of the acyl binding pocket of 'TesAthioesterase enhances octanoic acid production in E. coli. Metab Eng. 2020, 61:24-32. 

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    Liu Q., Guo X., Xun G., Li Z., Chong Y., Yang L., Wang H., Zhang F., Luo S., Cui L., Zhao P., Ye X., Xu H., Lu H., Li X., Deng Z., Li K., Feng Y.* Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations. Nucleic Acids Res. ,2021, gkab274.

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    Huang F, Xu X.Y., Dong H., Li N., Zhong B.Z., Lu H., Liu Q., Feng Y.*. Catalytic properties and biological function of a PIWI-RE nuclease from Pseudomonas stutzeri. Bioresour. Bioprocess. 2022,9, 57.

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    Zheng L., Lu H.,  Zan B., Li S., Liu H., Liu Z., Huang.J, Liu Y, Jiang F., Liu Q.*, Feng Y., Hong L.*  Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity. Nucleic Acids Res., 2022, 7529–7544.

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    Cui L*., Cui, A., Li Q., Yang L., Liu H., Shao W., Feng Y.*. Molecular Evolution of an Aminotransferase Based on Substrate–Enzyme Binding Energy Analysis for Efficient Valienamine Synthesis. ACS Catal. 2022, 12(21): 13703-13714.

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    He Y., Li S., Wang J., Yang X., Zhu J., Zhang Q., Cui  L., Tan Z., Yan W., Zhang Y., Tang L., Da L*., Feng Y*. Discovery and Engineering of the  l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation. ACS Catal. 2022, 13(11): 7210-7220.

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    Wu Z., Liu H., Xu L., Chen H., Feng Y*. Algorithm-based Coevolution Network Identification Reveals Key Functional Residues of the α/β Hydrolase Subfamilies. FASEB J. 2020, 34(2): 1983-1995. 

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    Sun Z., Liu Q., Qu G., Feng Y*., Reetz M*. Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability. Chem Rev. 2019, 119(3): 1626-1665. 

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    Tan Y., Zhang Y., Han Y., Liu H., Chen H., Ma F., Withers S., Feng Y., Yang G.*, Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method. Sci Adv. 2019, 5: eaaw8451.