Using genetic knockout mice as animal models, we investigated into the molecular mechanism underlying the bone development and remodeling, which involves the coupling of osteoblast and osteoclast differentiation processes. Our research would provide novel insights into the therapeutic strategies of degenerative bone diseases, such as osteoporosis and osteoarthritis.  

   The senescence of mesenchymal stem cells underlies a variety of aging-related diseases. Recently it is a prevaling strategy to treat these diaseases with senolytic method. We have revealed Foxp1 as a transcription factor in regulating senescence of mesenchymal stem cells（MSC), which is a potential target for the treatment of aging diseases.  

   Obesity and related diabetes are one of the plagues of our properity time.  We are going to explore the mechanisms of the development of obesity and diabetes from the prespectives of human evolution, alterations of human genome structure and life styles.