Sun RZ, You RX, Yu XC, Zhao D, Li L*. Discovery and synthesis of a Gram-negative-active cationic lipopeptide antibiotic inspired by primary sequences from underexplored Gram-negative bacteria. Organic Letters 2024; 26:1348-1352.
Li L*. Accessing hidden microbial biosynthetic potential from underexplored sources for novel drug discovery. Biotechnology Advances 2023; 66:108176.
Li L, Koirala B, Hernandez Y, MacIntyre LW, Russo R, Ternei MA, Brady SF*. Identification of structurally diverse menaquinone-binding antibiotics with in vivo activity against multidrug-resistant pathogens. Nature Microbiology 2022; 7:120-131.
Li L, MacIntyre LW, Ali T, Russo R, Koirala B, Hernandez Y, Brady SF*. Biosynthetic interrogation of soil metagenomes reveals metamarin, an uncommon cyclomarin congener with activity against Mycobacterium tuberculosis. Journal of Natural Products 2021; 84:1056-1066.
Li L, Liu XC, Wei KK, Lu YH*, Jiang WH*. Synthetic biology approaches for chromosomal integration of genes and pathways in industrial microbial systems. Biotechnology Advances 2019; 37(5):730-745.
Li L, Wei KK, Zheng GS, Liu XC, Chen SX, Jiang WH*, Lu YH*. CRISPR-Cpf1 assisted multiplex genome editing and transcriptional repression in Streptomyces. Applied and Environmental Microbiology 2018; 84:e00827-18.
Li L, Zheng GS, Chen J, Ge M, Jiang WH*, Lu YH*. Multiplexed site-specific genome engineering for overproducing bioactive secondary metabolites in actinomycetes. Metabolic Engineering 2017; 40:80-92.
Li L, Jiang WH*, Lu YH*. New strategies and approaches for engineering biosynthetic gene clusters of microbial natural products. Biotechnology Advances 2017; 35:936-949.
PDF
SUPP INOF