戴少波

长聘教轨副教授

  • 电话:+86-021
  • 邮箱:sdai@sjtu.edu.cn
  • 地址:上海市闵行区东川路800号上海交通大学闵行校区系统生物医学研究所C402室
  • 实验室网址:https://www.x-mol.com/groups/Dai_Shaobo
  • PI,博士生导师。阐述代谢关键酶的功能和催化机理,结合X射线晶体衍、酶动力学、光谱和化学生物学等对多种酶进行研究,包括硫胺素焦磷酸依赖酶和蛋白质甲基化酶,发表论文包括Nature, Nature Communications等。欢迎对酶学,蛋白质工程和化学生物学感兴趣的同学加入。

学术经历

  • 2005–2009 西北大学,生命科学与技术(基地班),学士
  • 2009–2012 西北大学,生物化学与分子生物学,硕士
  • 2013–2017 哥廷根大学/马普所生物物理化学研究所(德国),分子酶学,博士
  • 2017–2021 MD安德森癌症中心(美国),博士后
  • 2021至今 上海交通大学,生命科学技术学院,长聘教轨副教授

研究方向

生物途径关键酶的抑制剂研究

生物途径关键酶的抑制剂研究

蛋白质工程与酶进化

蛋白质工程与酶进化

化学法和酶法合成天然产物

化学法和酶法合成天然产物

酶催化过程的结构、催化机理和中间体

酶催化过程的结构、催化机理和中间体

代表论著

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    Dai, S., Funk, L.-M., von Pappenheim, F. R., Sautner, V., Paulikat, M., Schröder, B., Uranga, J., Mata, R. A. & Tittmann, K. (2019) Low-barrier hydrogen bonds in enzyme cooperativity. Nature, 573(7775) 609-613. Recommended in F1000Prime.

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    Wilkinson A.W.*, Diep J.*, Dai S.*, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, Cowan T, Elias JE, Nagamine CM, Spudich JA, Cheng X, Carette JE, Gozani O (2019) SETD3 is an actin histidine methyltransferase that prevents primary dystocia. (*co-first authors) Nature, 565(7739) 372-376. Recommended in F1000Prime.

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    Zhihong Xiao, Jinyin Zha, Xu Yang, Tingting Huang, Shuxin Huang, Qi Liu, Xiaozheng Wang, Jie Zhong, Jianting Zheng, Rubing Liang, Zixin Deng, Jian Zhang*, Shuangjun Lin*, Shaobo Dai*. (2024) A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D. Nature Communications, 15(2128): 1-15.

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    Zhiyong Liu, Chengliang Xiao, Shuangjun Lin, Kai Tittmann*, Shaobo Dai*. (2023) Multifaceted Role of the Substrate Phosphate Group in Transketolase Catalysis. ACS Catalysis.

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    Xi-Wei Chen, Zhiyong Liu, Shaobo Dai*, Yi Zou*. (2024) Discovery, Characterization and Engineering of the Free l-Histidine C4-Prenyltransferase. Journal of the American Chemical Society. 2024, Aug 14. doi: 10.1021/jacs.4c08388.

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    Qinglong Shi, Xiu-Wen Kang, Zhiyong Liu, Pandaram Sakthivel, Hasil Aman, Rui Chang, Xiaoyu Yan, Yubin Pang, Shaobo Dai*, Bei Ding*, Juntao Ye*. (2023) Single-electron oxidation-initiated enantioselective hydrosulfonylation of olefins enabled by photoenzymatic catalysis. Journal of the American Chemical Society. 2024, 146(4): 2748-2756

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    Dai S., Horton J.R., Woodcock C.B., Wilkinson A.W., Zhang X., Gozani O., Cheng X. (2019) Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nature Communications 10(1) 3541

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    Dai S, Holt MV, Horton JR, Woodcock CB, Patel A, Zhang X, Young NL, Wilkinson AW, Cheng X. Characterization of SETD3 methyltransferase mediated protein methionine methylation. Journal of Biological Chemistry. 2020, 295, 10901-10910 (cover story).

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    Dai S, Horton JR, Wilkinson AW, Gozani O, Zhang X, Cheng X. An engineered variant of SETD3 methyltransferase alters target specificity from histidine to lysine methylation. Journal of Biological Chemistry. 2020, 295 (9), 2582-2589.

获奖情况

  • 2019年获得美国晶体学会(American Crystallographic Association)RCSB PDB 最佳墙报奖;
  • 2020年获得MD安德森癌症中心最佳论文奖;
  • 2021年获得MD安德森癌症中心Ben F. Love fellowship in Innovative Cancer Therapies。