闫武鹏

长聘教轨副教授

  • 电话:+86-
  • 邮箱:yanwupeng@sjtu.edu.cn
  • 地址:上海市东川路800号上海交通大学生命学院4号楼202室
  • 闫武鹏博士,博士生导师。本课题组的研究方向主要集中于使用生物化学、生物物理以及结构生物学等手段研究酶功能、蛋白工程、癌基因RAS和其下游信号蛋白的功能调控以及相关抗癌药物研发。从而在基础和应用两个方向解决相关科研问题。

学术经历

  • 教育经历:

2017.4-2020.11  美国弗雷德里克癌症研究国家实验室, 博士后、助理研究员II。

2016.4-2017.3    美国得克萨斯大学奥斯汀分校,博士后。

2009.8-2016.3    美国得克萨斯大学奥斯汀分校,生物化学,博士。

2004.8-2008.7    清华大学,生物科学与技术系,学士。

 

  • 工作经历:

2020.12-迄今     上海交通大学,长聘教轨副教授。

研究方向

癌基因RAS与其上下游信号蛋白的功能调控以及相关抗癌药物...

           

 

蛋白工程

                     

基于结构的抗癌药物研发与改进

                     

 

代表论著

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    Wang, X.*, Hu, S.*, Wang, J.*, Zhang, T.*, Ye, K., Wen, A., Zhu, G., Vegas, A., Zhang, L.#, Yan, W.# , Liu, X#. and Liu, P#. (2023) Biochemical and Structural Characterization of OvoA Th2: A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis. ACS Catalysis, 13, pp.15417-15426.

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    Ge, X.*, Long, Y.*, Wang, J.*, Gu, B., Yang, Z., Feng, Y., Zheng, S., Li, Y., Yan, W.#and Song, H.# (2023) Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy and protein engineering. Science China Chemistry, pp.1-10.

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    He, Y., Li, S., Wang, J., Yang, X., Zhu, J., Zhang, Q., Cui, L., Tan, Z., Yan, W., Zhang, Y. and Tang, L., et.al. (2023) Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation. ACS Catalysis, 13, pp.7210-7220.

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    Zhu, Guoliang*, Wupeng Yan*, Xinye Wang*, Ronghai Cheng*, Nathchar Naowarojna, Kun Wang, Jun Wang et al. (2022) Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues. JACS Au . https://doi.org/10.1021/jacsau.2c00248

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    Yan, W.,* Markegard, E.*, Dharmaiah S., Urisman A., Drew M., Esposito D., Scheffzek K., Nissley D., McCormick, F.* and Simanshu, D.K.* (2020) Structural insights into the SPRED1-neurofibromin-KRAS complex and disruption of SPRED1-neurofibromin interaction by oncogenic EGFR. Cell Reports, 32(3), 107909

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    Yan, W., Georgiou, G., Stone, E. and Zhang, Y. (2017) Structural rationale for the salt-dependence of engineered cystathionine- γ-lyase for methionine depletion. Biochemistry. 56 (6), 876-88

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    Lu W.C.*, Saha A.*, Yan W., Garrison K., Pandey R., Irani S., Tiziani S., Zhang Y.J., Georgiou G., DiGiovanni J., and Stone E. (2020) Enzyme-Mediated Depletion of Serum L-Met Abrogates Prostate Cancer Growth via Multiple Mechanisms without Evidence of Systemic Toxicity. PNAS, 117(23), 13000-13011.

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    Lee, C. H.*, Romain, G.*, Yan, W., Watanabe, M., Charab, W., Todorova, B., Lee J., Triplett, K.,et al. (2017). IgG Fc Domains that bind C1q but not effector Fc gamma receptors delineate that significance of complement-mediated cell cytotoxicity and phagocytosis in antibody function. Nature Immunology. 18 (10), 1173-1173

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    Cramer, S.*, Saha, A.*, Tadi, S.*, Tiziani, S., Yan, W., Triplett, K., Lamb, C., Alters, S., Johnson, D., Zhang, Y., DiGiovanni, J., Georgiou, G.*, and Stone, E.* (2016). Systemic depletion of serum L-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice. Nature Medicine. 23, 120–127