Tenure-track Associate Professor
Wang, X.*, Hu, S.*, Wang, J.*, Zhang, T.*, Ye, K., Wen, A., Zhu, G., Vegas, A., Zhang, L.#, Yan, W.# , Liu, X#. and Liu, P#. (2023) Biochemical and Structural Characterization of OvoA Th2: A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis. ACS Catalysis, 13, pp.15417-15426.
Ge, X.*, Long, Y.*, Wang, J.*, Gu, B., Yang, Z., Feng, Y., Zheng, S., Li, Y., Yan, W.#and Song, H.# (2023) Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy and protein engineering. Science China Chemistry, pp.1-10.
He, Y., Li, S., Wang, J., Yang, X., Zhu, J., Zhang, Q., Cui, L., Tan, Z., Yan, W., Zhang, Y. and Tang, L., et.al. (2023) Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation. ACS Catalysis, 13, pp.7210-7220.
Zhu, Guoliang*, Wupeng Yan*, Xinye Wang*, Ronghai Cheng*, Nathchar Naowarojna, Kun Wang, Jun Wang et al. (2022) Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues. JACS Au . https://doi.org/10.1021/jacsau.2c00248
Yan, W.,* Markegard, E.*, Dharmaiah S., Urisman A., Drew M., Esposito D., Scheffzek K., Nissley D., McCormick, F.* and Simanshu, D.K.* (2020) Structural insights into the SPRED1-neurofibromin-KRAS complex and disruption of SPRED1-neurofibromin interaction by oncogenic EGFR. Cell Reports, 32(3), 107909
Yan, W., Georgiou, G., Stone, E. and Zhang, Y. (2017) Structural rationale for the salt-dependence of engineered cystathionine- γ-lyase for methionine depletion. Biochemistry. 56 (6), 876-88
Lu W.C.*, Saha A.*, Yan W., Garrison K., Pandey R., Irani S., Tiziani S., Zhang Y.J., Georgiou G., DiGiovanni J., and Stone E. (2020) Enzyme-Mediated Depletion of Serum L-Met Abrogates Prostate Cancer Growth via Multiple Mechanisms without Evidence of Systemic Toxicity. PNAS, 117(23), 13000-13011.
Lee, C. H.*, Romain, G.*, Yan, W., Watanabe, M., Charab, W., Todorova, B., Lee J., Triplett, K.,et al. (2017). IgG Fc Domains that bind C1q but not effector Fc gamma receptors delineate that significance of complement-mediated cell cytotoxicity and phagocytosis in antibody function. Nature Immunology. 18 (10), 1173-1173
Cramer, S.*, Saha, A.*, Tadi, S.*, Tiziani, S., Yan, W., Triplett, K., Lamb, C., Alters, S., Johnson, D., Zhang, Y., DiGiovanni, J., Georgiou, G.*, and Stone, E.* (2016). Systemic depletion of serum L-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice. Nature Medicine. 23, 120–127