D. Chen, J. Li, Y. Wu, L. Hong and Y. Liu. Structural dynamics-guided engineering of a riboswitch RNA for evolving c-di-AMP synthases. Sci. Adv. (2025) 11: eadt8165.

D. Chen, Z. Han, X. Liang, and Y. Liu. Engineering a DNA polymerase for modifying large RNA at specific positions. Nat. Chem. (2025) 17: 382.

X.Liang, D. Chen, A. Su, and Y. Liu. Divergent molecular assembly and catalytic mechanisms between bacterial and archaeal RNase P in pre-tRNA cleavage. PNAS (2024) 121: e2407579121.

L. Gao, D. Chen, and Y. Liu. Ligand Response of Guanidine-IV riboswitch at Single-molecule Level. eLife (2024) 13: RP94706.

Yanyan Xue, Jun Li, Dian Chen, Xizhu Zhao, Liang Hong, and Yu Liu. Observation of structural switch in nascent SAM-VI riboswitch during transcription at single-nucleotide and single-molecule resolution. Nat. Comm. (2023) 14: 2320.

S. Wang, D. Chen, L. Gao, and Y. Liu. Short Oligonucleotides Facilitate Co-transcriptional Labeling of RNA at Specific Positions. JACS (2022) 144: 5494.

Stagno, J., Y.Liu, et. al. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature (2017) 541: 242.

Y. Liu, E. Holmstrom, et. al. Incorporation of isotopic, fluorescent, and heavy-atom-modified nucleotides into RNAs by position-selective labeling of RNA. Nature Protocols (2018) 13: 987.

Y. Liu, E. Holmstrom, et. al. Synthesis and applications of RNAs with position-selective labeling and mosaic composition. Nature (2015) 522: 368.

Related Highlights: A machine to manage modifications, Nature Methods (2015) 12: 598.