Yawen He

  • Tel: +86-13564385795
  • Email: yawenhe@sjtu.edu.cn
  • Address: Dongchuan Road #800, Biology and Pharmacy Building 4D-303
  • Ya-Wen He received his BSc in Biology from Central China Normal University in 1992. He obtained his Ph.D. from National University of Singapore in 2006. He then worked as a research fellow at the Institute of Molecular and Cell Biology. In 2010, he joined Shanghai Jiaotong University as a principal investigator.

Selected Publications

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    He Ya-Wen*,#, Jin Z-J*, Cui Y, Song K, Chen B, Zhou L. RsaL is a self-regulatory switch that controls alternative biosynthesis of two AHL-type quorum sensing signals in Pseudomonas aeruginosa PA1201. mLife. 2024; 3: 74–86.

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    He Ya-Wen*,#, Deng Y*, Miao Y*, Chatterjee S, Tran TM, Tian J, Lindow S. DSF-family quorum sensing signal-mediated intraspecies, interspecies, and inter-kingdom communication. Trends in Microbiology, 2023 Jan;31(1):36-50.

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    Cui Y, Song K, Jin ZJ, Lee LH, Thawai C, He Ya-Wen. Fructose promotes pyoluteorin biosynthesis via the CbrAB-CrcZ-Hfq/Crc pathway in the biocontrol strain Pseudomonas PA1201. Synthetic and Systemic Biotechnology. 2023 Sep 21;8(4):618-628.

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    Song K, Chen B, Cui Y, Zhou L, Chan KG, Zhang HY, He Ya-Wen. The Plant Defense Signal Salicylic Acid Activates the RpfB-Dependent Quorum Sensing Signal Turnover via Altering the Culture and Cytoplasmic pH in the Phytopathogen Xanthomonas campestris. mBio. 2022,13(2): e0364421. 

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    Chen B, Li RF, Zhou L, Qiu JH, Song K, Tang JL, He Ya-Wen. The phytopathogen Xanthomonas campestris utilizes the divergently transcribed pobA/pobR locus for 4-hydroxybenzoic acid recognition and degradation to promote virulence. Molecular Microbiology. 2020, 114(5): 870-886.

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    Jin ZJ, Zhou L, Sun S, Cui Y, Song K, Zhang X, He Ya-Wen. Identification of a Strong Quorum Sensing- and Thermo-Regulated Promoter for the Biosynthesis of a New Metabolite Pesticide Phenazine-1-carboxamide in Pseudomonas strain PA1201. ACS Synthetic Biology. 2020 Jul 17;9(7):1802-1812.

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    Cao, XQ, Zhou L, Chen B, He Ya-Wen. Biosynthesis of Xanthomonas yellow pigment xanthomonadins involves an ATP-dependent 3- HBA:ACP ligase and an unusual type II polyketide synthesis pathway. Molecular Microbiology. 2018, Oct; 110(1):16-32.

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    Zhou L, Zhang LH, Cámara M, He Ya-Wen. The DSF Family of Quorum Sensing Signals: Diversity, Biosynthesis, and Turnover in Xanthomonas. Trends in Microbiology. 2017, 25(4):293-303.

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    Zhou Lian*, Wang Xing-Yu*, Sun Shuang, Yang Li-Chao, Jiang Bo-Le, He Ya-Wen. Identification and Characterization of Naturally Occurring DSF-Family Quorum Sensing Signal Turnover System in the Phytopathogen Xanthomonas. Environmental Microbiology, 2015, 17(11):4646–4658.

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    Jin Kaiming*, Zhou Lian*, Jiang Haixia, Sun Shuang, Fang Yunling, Liu Jianhua, Zhang Xuehong, He Ya-Wen. Engineering the central biosynthetic and secondary metabolic pathways of Pseudomonas aeruginosa strain PA1201 to improve phenazine-1-carboxylic acid production. Metabolic Engineering, 2015, 32:30-38.