Geng Wu

Professor

  • Tel: +86-021-34205914
  • Email: geng.wu@sjtu.edu.cn
  • Address:
  • PhD, Princeton University, 2001. In 2008, he founded the 1st structural biology lab of Shanghai Jiao Tiong Univ. He published in Nature, Science, Mol Cell, Nat Microbiol, Nat Commun as first/corresponding author and received the First Prize in Natural Science, Ministry of Education. His student was awarded Shanghai Excellent PhD thesis.

Selected Publications

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    Xiong X#, Wu G#, Wei Y#, Liu L, Zhang Y, Su R, Jiang X, Li M, Gao H, Tian X, Zhang Y, Hu L, Chen S, Tang Y, Jiang S, Huang R, Li Z, Wang Y, Deng Z, Wang J, Dedon PC, Chen S, Wang L. SspABCD-SspE is a phosphorothioation-sensing bacterial defence system with broad anti-phage activities. Nature Microbiology 2020 Apr 6. [Epub ahead of print](2020,第一作者)

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    Liu G, Fu W, Zhang Z, He Y, Yu H, Wang Y, Wang X, Zhao YL, Deng Z, Wu G*, He X*. Structural basis for the recognition of sulfur in phosphorothioated DNA. Nature Communications 9(1):4689.(2018,通讯作者)

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    Kulaberoglu Y#, Lin K#, Holder M, Gai Z, Gomez M, Shifa BA, Mavis M, Hua L, Sharif AAD, Lujan C, Smith EJ, Bjedov I, Tapon N, Wu G*, Hergovich A*. Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. Nature Communications 8:695.(2017,通讯作者)

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    Zhang Y, Fu L, Qi X, Zhang Z, Xia Y, Jia J, Jiang J, Zhao Y*, Wu G*. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nature Communications 4:2608.(2013,通讯作者)

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    Liu L, Jiang S, Xing M, Chen C, Lai C, Li N, Liu G, Wu D, Gao H, Hong L, Tan P, Chen S, Deng Z, Wu G*, Wang L*. Structural analysis of an L-cysteine desulfurase from an Ssp DNA phosphorothioation system. mBio in Press.(2020,通讯作者)

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    Gai Z, Chu W, Deng W, Li W, Li H, He A, Nellist M, Wu G*. Structure of the TBC1D7-TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region. Journal of Molecular Cell Biology 8:411-425.(2016,通讯作者)

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    Zhang Z, Chen L, Gao L, Lin K*, Zhu L, Lu Y, Shi X, Gao Y, Zhou J, Xu P, Zhang J*, Wu G*. Structural basis for the recognition of Asef by Adenomatous Polyposis Coli. Cell Research 22:372-386.(2012,通讯作者,被英国皇家学会院士Mariann Bienz选入Faculty of 1000生物医药类论文权威数据库)

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    Wu G, Xu G, Schulman B, Jeffrey P, Harper JW, Pavletich NP*. Structure of a β-TrCP1–Skp1–β-Catenin complex: destruction-motif binding and lysine specificity of the SCFβ-TrCP1 ubiquitin ligase. Molecular Cell 11:1445-1456. (2003)

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    Wu G#, Chai J#, Suber T, Wu JW, Du C, Wang X, Shi Y*. Structural basis of IAP recognition by Smac/DIABLO. Nature 408:1008-1012.(2000,第一作者,被Novartis、Genentech等公司作为设计抗癌药物的依据)

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    Wu G#, Chen YG#, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massague J, Shi Y*. Structural basis of Smad2 recognition by the Smad Anchor for Receptor Activation. Science 287:92-97. (2000,第一作者)