Rui Qing

  • Tel: +86 021
  • Email: ruiqing.br@sjtu.edu.cn
  • Address: Room C405, Center for System Biomedicine, SJTU
  • Rui Qing is a dedicated researcher in both materials science and molecular biology. His specialty includes membrane protein design, biosensing, and functional nanomaterials design. His future research interests are ML based protein design algorithms and molecular level bio-electronic integration.

Education and Research Experience

  • 2021-Present School of Life Sciences and Technology, Shanghai Jiao Tong University - Tenure Track Associate Professor
  • 2019-2021 The Koch Institute for Integrative Cancer Research, Massachusetts Insititute of Technology - Senior Postdoctoral Associate and Research Scientist
  • 2014-2019 The Media Lab, Massachusetts Insititute of Technology - Postdoctoral Associate
  • 2013-2014 University of Florida - Postdoctoral Scientist
  • 2007-2013 University of Florida - Ph.D. (Materials Science and Engineering)
  •                                                     - M.Sc. (Materials Science and Engineering and Industrial and System Engineering)
  • 2003-2007 Tongji University - B.Sc. (Materials Science and Engineering)

Research Interests

Membrane protein design

Regulation and optimization of membrane protein structure and functions via rational design tools including the QTY code.

Machine learning based protein design algorithms

De novo protein design or the optimizations of functions and properties of proteins based on their primary sequences and 3D conformations, via generative models such as the diffusion model.

 

Therapeutic development of membrane proteins

Elucidating molecular structures and mechanistic pathways of native membrane proteins through design method. Develop antibody-like decoy receptors as novel therapeutic agents.

Molecular-level integration of nanoscale bioelectronic interfaces

Integrating functional biomolecules into miniature electrical devices for chemically specific interfaces at low-molecular level to enable real-time bioelectronic communications that can be used in next-gen wearables and implants.

Selected Publications

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    R. Qing|*, M. Xue|, J. Zhao, L. Wu, A. Breitwieser, E. Smorodina, T. Schubert, G. Azzellino, D. Jin, J. Kong, T. Palacios*, U. Sleytr, S. Zhang*. “Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays”, Science Advances, 9, 29, (2023) eadf1402.

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    R. Qing*, S. Hao*, E. Smorodina, D. Jin, A. Zalevsky, S. Zhang. “Protein Design: From the Aspect of Water Solubility”, Chemical Reviews, 122, 18, (2022) 14085-14179.

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    R. Meng, S. Hao*, C. Sun, Z. Hou, Y. Hou, L. Wang, P. Deng, P. Deng, J. Deng, Y. Yang, H. Xia, B. Wang*, R. Qing*, S. Zhang*. “Reverse-QTY code design of active human serum albumin self-assembled amphiphilic nanoparticles for effective anti-tumor drug doxorubicin release in mice”, Proceedings of the National Academy of Sciences, 120, 21, (2023) e2220173120.

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    R. Qing*, Q. Han, M. Skuhersky, M. Badr, H. Chung, T. Schubert, S. Zhang*. “QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity”, Proceedings of the National Academy of Sciences, 116-51, (2019) 25668-25676.

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    R. Qing|*, F. Tao|, P. Chatterjee|, G. Yang, Q. Han, H. Chung, J. Ni, B. Suter, J. Kubicek, B. Maertens, T. Schubert, C. Blackburn, S. Zhang*. “Non-full-length water-soluble CXCR4QTY and CCR5QTY chemokine receptors: implication for overlooked truncated but functional membrane receptors”, 23-12, iScience, (2020) 101670.

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    L. Chen, R. Meng, R. Qing, W. Li, Z. Wang, Y. Hou, J. Deng, W. Pu, Z. Gao, B. Wang, S. Hao*.  “Bioinspired Robust Keratin Hydrogels for Biomedical Applications”, Nano Letters, 22, 22, (2022) 8835-8844.

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    S. Hao, D. Jin, S. Zhang*, R. Qing*. “QTY code designed water-soluble Fc-fusion cytokine receptors bind to their respective ligands”, QRB Discovery, 1-18, (2020).

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    P. Chatterjee*, N. Jakimo, J. Lee, N. Amrani, T. Rodriguez, S. Koseki, R. Qing, S. Hao, E. J. Sontheimer, J. M. Jacobson*. “An engineered ScCas9 with broad PAM range and high specificity and activity”, Nature Biotechnology, 38-10, (2020) 1212.

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    R. Qing, W. Sigmund*. “Bi-functional CexZr1−xO2 semiconductor nanoparticles with UV light switch”, Journal of Photochemistry and Photobiology A: Chemistry, 266, (2013) 55-63.

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    S. Zhang*, F. Tao, R. Qing, H. Tang, M. Skuhersky, K. Corin, L. Tegler, A. Wassie, B. Wassie, Y. Kwon, B. Suter, C. Entzian, T. Schubert, G. Yang, J. Labahn, J. Kubicek, B. Maertens. “QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities”, Proceedings of the National Academy of Sciences, 115-37, (2018) E8652-E8659.

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    W Li, R Qing, H Zhang, Z Wang, Y Yuan, L Wang, J Deng, B Wang, S Hao*. “Cellular mechanisms driving the distinct behavior of trichocyte keratins in wound healing”, Advanced Functional Materials, (2023) 2307634.

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