Lingxin Kong

  • Tel: +86-021
  • Email: konglingxin7@sjtu.edu.cn
  • Address:

Selected Publications

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    • Kong L, Wang Q, Yang W, Shen J, Li Y, Zheng X, Wang L, Chu Y, Deng Z, Chooi Y-H, You D.  Three recently diverging duplicated methyltransferases exhibit substrate-dependent regioselectivity essential for xantholipin biosynthesis. ACS Chem. Biol. 2020; 15(8): 2107-2115.

     

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    • Kong L, Wang Q, Deng Z, You D. Flavin adenine dinucleotide-dependent halogenase XanH and engineering of multifunctional fusion halogenases. Appl. Environ. Microbiol. 2020; 86(18).
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    • Kong L, Zhang W, Chooi YH, Wang L, Cao B, Deng Z, Chu Y, You D. A multifunctional monooxygenase XanO4 Catalyzes Xanthone Formation in xantholipin biosynthesis via a cryptic demethoxylation. Cell Chem.Biol. 2016, 23(4):508-516
       
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    Li J, Chen Y, Zheng T, Kong L, Zhu S, Sun Y, Deng, Yang L, You D. Quantitative mapping of DNA phosphorothioatome reveals phosphorothioate heterogeneity of low modification frequency, PLoS Genet. 2019, 15(4):e1008026.
     

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    Li Y, Kong L, Shen J, Wang Q, Liu Q, Yang W, Deng Z, You D. Characterization of the positive SARP family regulat or PieR for improving piericidin A1 production in Streptomyces piomogeues var. Hangzhouwanensis. Synth. Syst. Biotechnol. 2018, 4(1):16-24.
     

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    Shen J, Kong L, Li Y, Zheng X, Wang Q, Yang W, Deng Z, You D. A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in Streptomyces hygrospinosus var. beijingensis. Synth. Syst. Biotechnol. 2019,4(1):40-48.
     

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    Zhang W, Wang L, Kong L, Wang T, Chu Y, Deng Z, You D. Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin. Chem. Biol. 2012,19(3):422-432 

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    Kong L,  Deng Z,  You D. Chemistry and biosynthesis of bacterial polycyclic xanthone natural products, Nat. Prod. Rep., 2022,39(11):2057-2095 

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    Wang Q, Kong L, Zheng X, Shen J, Wang J, Zhang D, Qiao Y, Wang J, Deng Z, You D. Acyltransferase AniI, a tailoring enzyme with broad substrate tolerance for high-level production of anisomycin. Appl.  Environ. Microbiol., 2021,87(14):e0017221.

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    Zhang D, Wang J, Qiao Y, Lin B, Deng Z, Kong L*, You D*. Genome Mining and Metabolic Profiling Reveal Cytotoxic Cyclodipeptides in Streptomyces hygrospinosus var. Beijingensis. Antibiotics. 2022,11(11):1463.