Geng Wu

Professor

  • Tel: +86-021-34205914
  • Email: geng.wu@sjtu.edu.cn
  • Address:
  • PhD, Princeton University, 2001. His reserch focus is on intracellular protein anticancer therapeutics and short-stranded DNA anticancer therapeutics. He published in Nature, Science, Mol Cell, Nat Catalysis, Nat Microbiol, Nat Commun as first or corresponding author and received the First Prize in Natural Science, Ministry of Education.

Selected Publications

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    Wu D, Tang Y, Chen S, He Y, Chang X, Zheng W, Deng Z, Li Z, Wang L*, Wu G*, Chen S*. The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex. Nature Catalysis 5, 1131-1144. (2022)

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    Fu W, Wu G*. Design of negative-regulating proteins of Rheb/mTORC1 with much-reduced sizes of the tuberous sclerosis protein complex. Protein Science 32 (8): e4731. (2023,通讯作者)

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    Gao H, Gong X, Zhou J, Zhang Y, Duan J, Wei Y, Chen L, Deng Z, Wang J, Chen S*, Wu G*, Wang L*. Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE. Nature Communications 13, 6773. (2022)

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    Gai Z, Wang Q, Yang C, Wang L, Deng W, Wu G*. Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway. Cell Discovery 2:16051.(2016)

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    Ramlaul K, Fu W, Li H, Garrido NM, He L, Cui W, Aylett CHS*, Wu G*. Architecture of the Tuberous Sclerosis Protein Complex. Journal of Molecular Biology 433(2):166743. (2020,通讯作者,被选入Faculty Opinions生物医药类论文权威数据库)

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    Mu Z, Wang L, Deng W, Wang J, Wu G*. Structural insight into the Ragulator complex which anchors mTORC1 to the lysosomal membrane. Cell Discovery 3:17049.(2017,通讯作者)

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    Kulaberoglu Y#, Lin K#, Holder M, Gai Z, Gomez M, Shifa BA, Mavis M, Hua L, Sharif AAD, Lujan C, Smith EJ, Bjedov I, Tapon N, Wu G*, Hergovich A*. Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control. Nature Communications 8:695.(2017,通讯作者)

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    Zhang Z, Akyildiz S, Xiao Y, Gai Z, An Y, Behrens J*, Wu G*. Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners. Cell Discovery 1: 15016. (2015,通讯作者)

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    Zhang Y, Fu L, Qi X, Zhang Z, Xia Y, Jia J, Jiang J, Zhao Y*, Wu G*. Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nature Communications 4:2608.(2013,通讯作者)

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    Zhang Z, Chen L, Gao L, Lin K*, Zhu L, Lu Y, Shi X, Gao Y, Zhou J, Xu P, Zhang J*, Wu G*. Structural basis for the recognition of Asef by Adenomatous Polyposis Coli. Cell Research 22:372-386.(2012,通讯作者,被英国皇家学会院士Marian Bienz选入Faculty of 1000生物医药类论文权威数据库)