左浩

长聘教轨副教授

  • 电话:+86-021
  • 邮箱:zuohao@sjtu.edu.cn
  • 博士生导师。围绕机体钙稳态调控与骨健康相关科学问题,综合运用结构生物学、生物化学及动物模型等研究手段,系统探究钙信号在骨代谢平衡及骨相关疾病发生发展中的分子机制,解析钙离子及激素等信号分子调控细胞表面膜蛋白受体功能的分子基础。

学术经历

  • 2005-2009 学士 上海交通大学
  • 2009-2013 博士 香港科技大学
  • 2013-2024 博士后 哥伦比亚大学、德克萨斯大学西南医学中心

研究方向

细胞表面受体蛋白复杂复合物的结构

结构生物学方法解析复杂蛋白复合物的分子构造

膜蛋白相关的肿瘤、代谢、神经等相关疾病的致病机理和治...

探索细胞表面膜蛋白与相关疾病的关系与治疗

基于受体结构的药物分子设计

以受体蛋白的分子结构为基础进行药物分子设计和优化

代表论著

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    Hao Zuo1, Jinseo Park1, Aurel Frangaj, Jianxiang Ye, Guanqi Lu, Jamie J. Manning, Wesley B. Asher, Zhengyuan Lu, Guobin  Hu, Liguo Wang, Joshua Mendez, Edward Eng, Zhening Zhang, Xin Lin, Robert Grasucci, Wayne A. Hendrickson, Oliver B. Clarke, Jonathan A. Javitch, Arthur D. Conigrave, Qing R. Fan: Promiscuous G-protein activation by the calcium-sensing receptor. Nature (2024) 629(8011):481-488.

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    Jinseo Park1Hao Zuo1, Aurel Frangaj1, Ziao Fu1, Laura Y. Yen1, Zhening Zhang1, Lidia Mosyak, Vesna N. Slavkovich, Jonathan Liu, Kimberly M. Ray, Baohua Cao, Francesca Vallese, Yong Geng, Shaoxia Chen, Robert Grassucci, Venkata P. Dandey, Yong Zi Tan,  Edward Eng, Yeji Lee, Brian Kloss, Zheng Liu, Wayne A. Hendrickson, Clinton S. Potter,  Bridget Carragher, Joseph Graziano, Arthur D. Conigrave, Joachim Frank,  Oliver B. Clarke, and  Qing R. Fan: Symmetric activation and modulation of the human calcium-sensing receptor. Proc. Natl. Acad. Sci. USA. (2021) 118 (51) e2115849118.

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    Hao Zuo1, Dengbao Yang1, Yihong Wan: Fam20C regulates bone resorption and breast cancer bone metastasis through osteopontin and BMP4. Cancer Research (2021) 81 (20), 5242-5254.

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    Hao Zuo, Dengbao Yang, Qiwen Yang, Haidong Tang, Yang-Xin Fu, Yihong Wan: Differential Regulation of Breast Cancer Bone Metastasis by PARP1 and PARP2. Nature Communications (2020) 11, 1578.

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    Hao Zuo1, Ian Glaaser1, Yulin Zhao1, Igor Kurinov1, Lidia Mosyak1, Haonan Wang1, Jonathan Liu1, Jinseo Park, Aurel Frangaj, Emmanuel Sturchler, Ming Zhou, Patricia McDonald, Yong Geng, Paul Slesinger, Qing Fan: Structural basis for auxiliary subunit KCTD16 regulation of the GABAB receptor. Proc. Natl. Acad. Sci. USA. (2019) 116(17), 8370-‌8379.