蔡旖斐

长聘教轨副教授

  • 电话:+86-021
  • 邮箱:yifeicai@sjtu.edu.cn
  • 地址:上海市闵行区东川路800号Bio-X研究院
  • 实验室网址:https://www.yifeicai.com/
  • 本课题组聚焦于神经元-胶质细胞-血管互作在神经退行性疾病中的作用,主要关注其对神经信号传导和轴突-髓鞘病变的影响。研究运用人脑组织、小鼠模型及iPSC建模,结合邻近标记蛋白质组学、组织与在体成像、基因操控等手段,解析相关信号通路与细胞机制,致力于发现有临床价值的新靶点。

学术经历

  • 博    士 (2013-2018) 北京大学
  • 博士后  (2018-2023) 耶鲁大学
  • 助理研究员  (2023-2026) 耶鲁大学
  • 长聘教轨副教授 (2026至今)上海交通大学

研究方向

少突胶质细胞谱系细胞在神经退行性疾病中的作用及其对轴...

少突胶质细胞谱系细胞在神经退行性疾病中的作用及其对轴突病理的调控

解析血管-胶质细胞-轴突互作轴,揭示神经免疫微环境对轴...

解析血管-胶质细胞-轴突互作轴,揭示神经免疫微环境对轴突-髓鞘病变的调控

开发人脑细胞特异性蛋白质组学、iPSC疾病建模、细胞特异...

开发人脑细胞特异性蛋白质组学、iPSC疾病建模、细胞特异性标记AAV、以及多组学与组织成像整合等前沿研究工具

代表论著

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    Y. Cai†, I.P. Sousa∗, M. Slobodyanyuk∗, F. Chen∗, T. Huynh, P. Tang, L. Fuentes, A. Braker, R. Welch, A. Huttner, L. Tong, P. Yuan, T.T. Lam, A.C. Nairn, E. Petsalaki, J. Reimand, J. Grutzendler†. Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain. (2025) Nature Neuroscience. doi: 10.1038/s41593-025-01973-8. († 共同通讯)

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    Y. Cai†, J. Kanyo, R. Wilson, S. Bathla, P. Cardozo, L. Tong, S. Qin, L.A. Fuentes, I.Pinheiro-de-Sousa, T. Huynh, L. Sun, M. Mohammad, Z. Tian, H. Gan, A. Braker, K. Trinh, A. Huttner, T. T. Lam, E. Petsalaki, K. J. Brennand, A.C. Nairn, J. Grutzendler†. Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease. (2025) Nature Aging. doi: 10.1038/s43587-025-00823-3. († 共同通讯)

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    P. Yuan, M. Zhang, L. Tong, T.M. Morse, R.A. McDougal, H. Ding, D. Chan, Y. Cai, J. Grutzendler. PLD3 affects axonal spheroids and network defects in Alzheimer’s disease. Nature. 612, 328–337 (2022).

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     J. Mukai, E. Canavo, Z. Sun, A. Diamantopoulou, P. Thakur, C. Chang, Y. Cai, S. Lomvardas, A. Takata, B. Xu, J.A. Gogos. Recapitulation and reversal of schizophreniarelated phenotypes in Setd1a-deficient mice. Neuron. 104 (3): 471-487 (2019).

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     J. Guo, Y. Cai, X. Ye, N. Ma, Y. Wang, B. Yu, J. Wan. Regulation of neurite outgrowth by miR-409-5p is involved in Alzheimer’s disease development. Front. Neurosci. 13, 2164 (2019).

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    Y. Cai, J. Wan. Competing endogenous RNA regulations in neurodegenerative disorders: current challenges and emerging insights. Front. Mol. Neurosci. 11, 370 (2018).

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    Y. Cai, Z. Sun, H. Jia, H. Luo, X. Ye, Q. Wu, X. Yi, W. Zhang, J. Wan. Rpph1 upregulates CDC42 expression and promotes hippocampal neuron dendritic spine formation by competing with miR-330-5p. Front. Mol. Neurosci. 10, 27 (2017).

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    Y. Cai*, Z. Liang*, T. He, G. Zhang, J. Huang, X. Zeng. Augmenting LASSO regression with decision tree for identifying the correlation of genetic polymorphism and adverse events. IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 355-360 (2013).

获奖情况

  • 2026 - 2029    BrightFocus Alzheimer's Disease Research Standard Award, BrightFocus Foundation
  • 2025 - 2026    Pilot Project Award, Carol and Gene Ludwig Program for the Study of Neuroimmune Interactions in Dementia
  • 2023 - 2026    Alzheimer's Association Research Fellowship, Alzheimer's Association
  • 2023 – 2024   EMBL-CPP Fellowship, European Molecular Biology Laboratory (EMBL)
  • 2021 - 2023    BrightFocus Postdoc Fellowship in Alzheimer's Research, BrightFocus Foundation
  • 2026 - 2029    BrightFocus Alzheimer's Disease Research Standard Award, BrightFocus Foundation
  • 2025 - 2026    Pilot Project Award, Carol and Gene Ludwig Program for the Study of Neuroimmune Interactions in Dementia
  • 2023 - 2026    Alzheimer's Association Research Fellowship, Alzheimer's Association
  • 2023 – 2024   EMBL-CPP Fellowship, European Molecular Biology Laboratory (EMBL)
  • 2021 - 2023    BrightFocus Postdoc Fellowship in Alzheimer's Research, BrightFocus Foundation

承担项目

学生培养

  • 在读学生
  • 毕业学生