教授/长聘副教授
随着蛋白质组学研究的深入，迫切需要发展针对亚细胞蛋白质组的分离分析新技术。根据不同亚细胞蛋白质组的特点，结合纳米材料构建亚细胞蛋白质组研究核心方法。
围绕生物对象开展分离分析新技术新方法新材料研究，特别是针对蛋白质与核酸的分离新材料等，发展修饰蛋白的分离、定性、定量和结构解析新技术和新方法，为蛋白质组学、蛋白质翻译后修饰及其功能研究提供技术支持。
无创分子诊断对癌症的筛查、诊断和治疗非常关键，是生物分离分析的重要研究方向。在已有分离分析新技术新方法以及外泌体研究等技术基础上，结合国家战略需求和实际临床需要，发展用于癌症早期诊断、早期预警和早期干预治疗的新技术新途径。
外泌体在癌症的发生发展过程中起着非常重要的作用，同时也是潜在的癌症诊断标志物和治疗载体。针对体液与细胞外泌体，发展分离分析新技术，开展外泌体蛋白质组及其翻译后修饰研究，拓展外泌体的功能研究与临床应用。
Wang, Z.Y., Wu, L.H., Guo, M., Zhu, J.Z., Zhao, J.Q., Wu., Y., Xiao, H., Zhang, Y., Activation of dimerized BRS3-EP3 suppresses melanoma cell migration through coupling G s protein, Fundamental Research 2024, Accepted.
Wang, H.Y., Zhang, Y., Wang, Z.Y., Zhang, L., Guo, M., Cao, C.X., Xiao, H., Deciphering nucleic acid binding proteome of mouse immune organs reveals hub proteins for aging, Mol. Cell. Proteomics 2023, 22(8):100611
Wu, L.H., Cui, J.H., Zhao, C.X., Wang, Z.Y., Lu, J.H., Li, S.S., Jia, J.P., Xiao, H., Zhang, Y., Discovery of Dimethyl Shikonin Oxime 5a, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Type 2 Diabetes Mellitus, J. Med. Chem. 2023, 66(12):8011-8029.
Jiang, X.T., Zhang, Y., Wang, H.Y., Wang, Z.Y., Hu, S., Cao, C.X., Xiao, H., In-Depth Metaproteomics Analysis of Oral Microbiome for Lung Cancer. Research. 2022, 2022: 9781578.
Sohail, A., Jiang, X.T., Wahid, A., Wang, H.Y., Cao, C.X., Xiao, H., Free-flow zone electrophoresis facilitated proteomics analysis of heterogeneous subpopulations in H1299 lung cancer cells. Anal. Chim. Acta 2022, 1227: 340306.
Zhang, B.H., Guo, M., Wang, H.Y., Wang, Z.Y., Zhang, L., Zhang, Y., Cao, C.X., Xiao, H., Metal organic framework nanomaterial based extraction and proteome analysis of membrane and membrane-associated proteins. Anal. Chem. 2021, 93(48):15922-15930.
Jiang, X.T., Liu, S., Zhang, Y., Ji, Y., Sohail, A., Cao, C.X., Wang, P., Xiao, H., Free-Flow Isoelectric Focusing for comprehensive separation and analysis of human salivary microbiome for lung cancer. Anal. Chem. 2020, 92(17):12017-12025
Liu, S., Jiang, X.T., Shang, Z., Ji, Y., Wang, H.Y., Wang, Z.Y., Wang, P., Zhang, Y., Xiao, H., N-glycan structures of target cancer biomarker characterized by two-dimensional gel electrophoresis and mass spectrometry. Anal. Chim. Acta 2020, 1123:18-27.
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