孟祥周

长聘教轨副教授

  • 电话:+86-021
  • 邮箱:mengx@sjtu.edu.cn
  • 长聘教轨副教授,博士生导师,主要研究真核生物DNA复制的分子机制,DNA复制及修复蛋白在维持基因组稳定性中的作用与抑癌原理。

学术经历

  • 2020.12-至今,上海交通大学,长聘教轨副教授,博导
  • 2016-2020 美国纪念斯隆癌症中心,博士后
  • 2009-2015 美国德克萨斯农工大学,生物化学,博士
  • 2006 -2009 山东大学,微生物学,硕士
  • 2002-2006 山东大学,生物基地班,学士

研究方向

真核生物DNA复制的分子机制

真核生物DNA复制的分子机制

DNA复制与修复蛋白在维护基因组稳定性中的作用

DNA复制与修复蛋白在维护基因组稳定性中的作用

DNA聚合酶的抑癌机制

DNA聚合酶的抑癌机制

代表论著

  • •  

    Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, Zhao X. (2023) Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Genes & Development. doi:10.1101/gad.350054.122

    •  


    Meng X, Dang HQ, Kapler GM. (2023) Developmentally Programmed Switches in DNA Replication: Gene Amplification and Genome-Wide Endoreplication in Tetrahymena. Microorganisms. 11 (2), 491.

    •  

    Meng X, Wei L, Devbhandari S, Zhang T, Xiang J, Remus D, Zhao X*. (2020) DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. Nat Commun. 11(1):2437.

    •  

    Meng X#, Wei L#, Peng XP, and Zhao X*. (2019) Sumoylation of DNA polymerase ε by the Smc5/6 complex contributes to DNA Replication. PLoS Genet. 15(11):e1008426.

    •  

    Meng X, Zhao X*. (2017) Replication fork regression and its regulation. FEMS Yeast Res. 17(1):fow110.

  • •  

    Dhingra N, Kuppa S, Wei L, Pokhrel N, Baburyan S, Meng X, Antony E, Zhao X. (2021) The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin. Proc Natl Acad Sci U S A.118(8):e2020185118.

    •  

    Wan B, Wu J, Meng X, Lei M, Zhao X*. (2019) Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Mol Cell. 75(2):238-251.

    •  

    Lee PH#, Meng X#, Kapler GM*. (2015) Developmental regulation of the Tetrahymena thermophila origin recognition complex. PLoS Genet. 11(1):e1004875.

    •  

    Sandoval PY#, Lee PH#, Meng X#, Kapler GM*. (2015) Checkpoint activation of an unconventional DNA replication program in Tetrahymena. PLoS Genet. 11(7):e1005405.