长聘教轨副教授
开发体内成像学研究手段，研究以新生隐球菌为代表的病原真菌与宿主免疫系统互作，揭示其致病关键机制。
利用体内成像技术，研究革兰氏阴性菌导致的肺炎及脓毒症的时空动态与干预机制。
通过体内成像揭示肿瘤发生极早期的免疫响应时空动态，重点关注巨噬细胞的发育与功能。
通过成像学揭示纳米载体的体内行为动态与靶向性，揭示影响其体内行为与分布的调控机制，设计在不同病理条件下适用的巨噬细胞靶向性纳米载体。
Feng C, Wang G, Wang Y, Gao X, Xu Z, Fang L, Ma Z, Zheng S, Xie Y, Chu Y, Meng M, Yang A, Lu M, Mondina J, Zhu W, Zhang L, Wang L, Chen Z, Sun D. Microglia sense fungal infections through capsular components from capillary-bound Cryptococcus neoformans via endothelial nucleotide signaling. PLoS Biology 2026 24(2): e3003642.
Wang, G., Feng, C., Ma, Z., Zhao, L., Yosri, M., Wang, Y., Gao, X., Zhu, W., Li, H., Song, H., Xia, J., Meng, M., Lu, H., Zhang, L., Chen, Z., & Sun, D. (2025). In toto imaging shows intravascular proliferation promotes transmigration of daughter cells during brain invasion of Cryptococcus neoformans. Cell reports, 44(12), 116658.
Du, Z*., Wei, W., Lu, S., Wang, H., Feng, C., Li, Y., Cui, X., Zhe, J., Sun, K., Liu, K., Fan, Q., Sun, D*., & Bao, W*. PCL-PEtOx-based Crystalline-core Micelles for the Targeted Delivery of Paclitaxel and Trabectedin in Ovarian Cancer Therapy. Acta biomaterialia, 2025, 200, 536–553.
Xu LB, Feng XB*, Wang DZ, Gao F, Feng CX, Shan QJ, Wang G, Yang F, Zhang JF, Hou JW, Sun DL*, Wang TS*. Improved Liver Intravital Microscopic Imaging Using a Film-Assisted Stabilization Method. ACS Sensors. 2024.
Sun D#, Sun P#, He S, Shi M. Rat IgG mediated circulatory cell depletion in mice requires mononuclear phagocyte system and is facilitated by complement. Journal of Leukocyte Biology. 2020 107:529–539.
Sun D, Sun P, Li H, Zhang M, Liu G, Strickland AB et al.. Fungal dissemination is limited by liver macrophage filtration of the blood. Nature Communications 2019 10 (1), 1-14. (F1000 Recommended)
Liu G, Fu Y, Yosri M, Chen Y, Sun P, Xu J, Zhang M, Sun D et al.. CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement Proceedings of the National Academy of Sciences 2019 116 (48), 24214-24220.
Sun D, Zhang M, Liu G, Wu H, Li, Zhou H, Zhang X, Shi M. Intravascular clearance of disseminating Cryptococcus neoformans in the brain can be improved by enhancing neutrophil recruitment in mice. European Journal of Immunology 2016 46(7):1704-1714.
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