孙冬雷

长聘教轨副教授

  • 电话:021-34208469
  • 邮箱:dongleisun@sjtu.edu.cn
  • 地址:生命科学技术学院2-317
  • 实验室网址:life.sjtu.edu.cn/teacher/dongleisun
  • 本课题组研究方向是免疫与感染及重大疾病。研究以单核/巨噬细胞为中心,利用多种影像学技术研究不同来源的单核/巨噬细胞在动物疾病模型下的招募、分化和功能。另一个研究方向是单核/巨噬细胞功能的调控和干预,使其有效发挥功能的同时避免组织损伤。目前主持基金委和上海市科委多项科学基金。

学术经历

  • 2006-2010    华中科技大学 学士
  • 2010-2013    中国科学院武汉病毒研究所 硕士
  • 2013-2018    马里兰大学帕克分校 博士
  • 2018-2020    马里兰大学帕克分校 博士后
  • 2020-今        上海交通大学 长聘教轨副教授

研究方向

单核/巨噬细胞在动物疾病模型下的招募、分化和功能

研究不同种类的巨噬细胞在炎症和其他病理状态下的行为及功能

单核/巨噬细胞的调控

以脂质体,病毒载体等为工具,调节单核/巨噬细胞的功能

单核巨噬细胞在肿瘤微环境中的作用

揭示单核/巨噬细胞在肿瘤微环境中的作用,以最大程度发挥未来肿瘤治疗策略的功效

代表论著

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    Sun D*, Zhang M*, Sun P, Liu G, Strickland AB, Chen Y, et al.. VCAM1/VLA4 interaction mediates Ly6Clow monocyte recruitment to the brain in a TNFR signaling dependent manner during fungal infection. PLoS Pathogens 2020 16(2): e1008361.

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    Sun D*, Sun P*, He S, Shi M. Rat IgG mediated circulatory cell depletion in mice requires mononuclear phagocyte system and is facilitated by complement. Journal of Leukocyte Biology. 2020 107:529–539.

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    Sun DL*, Gao YZ*, Ge X*, Shi ZL, Zhou NY. Special features of bat microbiota differ from those of terrestrial mammals. Frontiers in Microbiology. 2020 11:1040.

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    Sun D, Sun P, Li H, Zhang M, Liu G, Strickland AB et al.. Fungal dissemination is limited by liver macrophage filtration of the blood. Nature Communications 2019 10 (1), 1-14. (F1000 Recommended)

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    Liu G, Fu Y, Yosri M, Chen Y, Sun P, Xu J, Zhang M, Sun D et al.. CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement Proceedings of the National Academy of Sciences 2019 116 (48), 24214-24220.

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    Sun D, Zhang M, Liu G, Wu H, Li, Zhou H, Zhang X, Shi M. Intravascular clearance of disseminating Cryptococcus neoformans in the brain can be improved by enhancing neutrophil recruitment in mice. European Journal of Immunology 2016 46(7):1704-1714.

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    Zhang M*, Sun D*, Liu G, Wu H, Zhou H, Shi M. Real-time in vivo imaging reveals the ability of neutrophils to remove Cryptococcus neoformans directly from the brain vasculature. Journal of Leukocyte Biology. 2016 99(3):467-473.

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    Sun D, Zhang M, Liu G, Wu H, Zhu X, Zhou H, Shi M. Real-time imaging of interactions of neutrophils with Cryptococcus neoformans demonstrates a crucial role of complement C5a-C5aR signaling. Infection and Immunity. 2015 84(1):216-229.

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    Sun D, Shi M. Neutrophil swarming toward Cryptococcus neoformans is mediated by complement and leukotriene B4. Biochemical and Biophysical Research Communications. 2016 477(4):945-951

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    Sun DL, Jiang X, Wu QL, Zhou NY. Intragenomic heterogeneity of 16S rRNA genes causes overestimation of prokaryotic diversity. Applied Environmental Microbiology. 2013 79(19):5962-9.

学生培养

  • 在读学生
  • 毕业学生