教授/长聘副教授
发展基于重组蛋白以及免疫活化的肿瘤疫苗和病原微生物疫苗
发展基于T细胞修饰的细胞过继性肿瘤治疗手段
发展基于抗体的靶向肿瘤免疫治疗手段
研究肿瘤微环境中的各种细胞组分对肿瘤免疫的抑制机理,发现新的肿瘤治疗靶点
发展基于重组蛋白以及免疫活化的肿瘤疫苗和病原微生物疫苗
发展基于T细胞修饰的细胞过继性肿瘤治疗手段
发展基于抗体的靶向肿瘤免疫治疗手段
研究肿瘤微环境中的各种细胞组分对肿瘤免疫的抑制机理,发现新的肿瘤治疗靶点
Xuanming Yang, Xunmin Zhang, Yonglian Sun, Tony Tu, Mendy Miller, Yang-Xin Fu. A BTLA-Mediated Bait and Switch Strategy Permits Listeria Expansion in CD8α(+) DCs to Promote Long-Term T Cell Responses. Cell Host & Microbe. 2014 Jul 9;16(1):68-80
Xiaohuan Guo, Ju Qiu, Tony Tu, Xuanming Yang, Liufu Deng, Robert A. Anders, Liang Zhou, Yang-Xin Fu. Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection. Immunity. 2014 Jan 7. pii: S1074-7613(13)00555-4.
Xuanming Yang, Xunmin Zhang, May Lynne Fu, Ralph R. Weichselbaum, Thomas F. Gajewski, Yajun Guo, Yang-Xin Fu. Targeting the tumor microenvironment with interferon- bridges innate and adaptive immune responses. Cancer Cell. 2014 Jan 13;25(1):37-48.
Ying He, Jikun Zha, Yamin Wang, Wenhua Liu, Xuanming Yang, and Ping Yu. Tissue damage-associated "danger signals" influence T-cell responses that promote the progression of preneoplasia to cancer. Cancer Res. 2013 Jan 15;73(2):629-39.
Xuanming Yang, Eric D Mortenson , Yang-Xin Fu. Targeting and utilizing primary tumors as live vaccines: changing strategies. Cell Mol Immunol. 2011 Nov 21. doi: 10.1038/cmi.2011.49.
Qi Da*, Xuanming Yang*, Xiaoqi Li, Youli Xu, Guangxia Gao, Genhong Cheng and Hong Tang. TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I J Immunol 2011;186;3023-3030 (*, Co-first Author)
SaeGwang Park, Zhujun Jiang, Eric D. Mortenson, Liufu Deng, Olga Radkevich-Brown, Xuanming Yang, Husain Sattar, Yang Wang, Nicholas K. Brown, Mark Greene, Yang Liu, Jie Tang, Shengdian Wang, Yang-Xin Fu. The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity. Cancer Cell. 2010 Aug 9;18(2):160-70.
Xiaoqi Li, Xuanming Yang, Youli Xu, Xuejun Jiang, Fajun Nan, Hong Tang. Troglitazone inhibits cell proliferation by attenuation of Epidermal Growth Factor Receptor Signaling independent of Peroxisome Proliferator-activated Receptor gamma. Cell Research. 2009: 720-732).