黄显清

副教授

  • 电话:
  • 邮箱:xqhuang66@sjtu.edu.cn, xqhuang66@126.com
  • 博士,副教授。主要从事假单胞菌抗生素合成的分子调控机制、网络、工程及应用研究。主持完成863课题1项、国家自然基金3项。以第一或通讯作者在Mol Microbiol、J Bacteriol等刊物上发表10多篇论文。参与的“申嗪霉素研制及应用”项目获2007年上海科技进步一等奖。

学术经历

  • 2005年4月毕业于上海交大生命学院生化与分子生物学专业,获理学博士学位,同年留校工作,07年12月起担任副教授。

研究方向

3. 微生物源农药及其它药物、高附加值产物的应用及开发研...

  

2. 微生物初级与次级代谢的全局调控网络、代谢工程及合成...

  

1. 假单胞菌抗生素合成的分子调控机制、网络及代谢工程

  

代表论著

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    [1] Zheng Wang, Xianqing Huang *, Malik Jan, Deyu Kong, Wei Wang, Xuehong Zhang *. 2021. Lon protease downregulates phenazine-1-carboxamide biosynthesis by degrading the quorum sensing signal synthase PhzI and exhibits negative feedback regulation of Lon itself in Pseudomonas chlororaphis HT66. Molecular Microbiology. 2021,116:690–706. (* Co-corresponding authors)

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    [2] Zheng Wang, Xianqing Huang *, Yujie Liu, Guohuan Yang, Yang Liu, Xuehong Zhang. 2017. GacS/GacA activates pyoluteorin biosynthesis through Gac/Rsm-RsmE cascade and RsmA/RsmE-driven feedback loop in Pseudomonas protegens H78. Molecular Microbiology 105: 968-985. (*Corresponding author)

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    [3] Zheng Wang, Xianqing Huang *, Chenxi Nie, Tao Xiang, Xuehong Zhang*. 2022. The Lon protease negatively regulates pyoluteorin biosynthesis through the Gac/Rsm-RsmE cascade and directly degrades the transcriptional activator PltR in Pseudomonas protegens H78. Environmental Microbiology Reports. 2022 Mar 16. doi:10.1111/1758-2229.13057. Online ahead of print. (*Corresponding authors)

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    [4] Zheng Wang, Xianqing Huang *, Malik Jan, Deyu Kong, Jingwen Pan, Xuehong Zhang *. 2021. The global regulator Hfq exhibits far more extensive and intensive regulation than Crc in Pseudomonas protegens H78. Molecular Plant Pathology.  doi:10.1111/mpp.13070. (Co-corresponding authors)

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    [5] Lingyu Wu#, Zheng Wang#, Yejun Guan, Xianqing Huang *, Huimin Shi, Yujie Liu, Xuehong Zhang. 2020. The (p)ppGpp-mediated stringent response regulatory system globally inhibits primary metabolism and activates secondary metabolism in Pseudomonas Protegens H78. Applied Microbiology and Biotechnology 104: 3061-3079. (# Co-first authors; * Corresponding author)

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    [5] Yujie Liu, Huimin Shi, Zheng Wang, Xianqing Huang*, Xuehong Zhang. 2018. Pleiotropic control of antibiotic biosynthesis, flagellar operon expression, biofilm formation, and carbon source utilization by RpoN in Pseudomonas protegens H78. Applied Microbiology and Biotechnology 102: 9719-9730. (*Corresponding author)

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    [4] Huimin Shi, Xianqing Huang*, Zheng Wang, Yejun Guan, Xuehong Zhang. 2019. Improvement of pyoluteorin production in Pseudomonas protegens H78 through engineering its biosynthetic and regulatory pathways. Applied Microbiology and Biotechnology 103: 3465-3476. (*Corresponding author)

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    [6] Xue Wei #, Xianqing Huang #,*, Lulu Tang, Daqiang Wu, Yuquan Xu *. 2013. Global control of GacA in secondary metabolism, primary metabolism, secretion systems, and motility in the rhizobacterium Pseudomonas aeruginosa M18. Journal of Bacteriology  195: 3387-3400.  (* Corresponding authors, #Co-first authors)

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    [7] Guohao Wang#, Xianqing Huang #,*, Sainan Li, Jiaofang Huang, Xue Wei, Yaqian Li, Yuquan Xu*. 2012. The RNA chaperone Hfq regulates antibiotic biosynthesis in the rhizobacterium Pseudomonas aeruginosa M18. Journal of Bacteriology 194: 2443-2457.  (*Corresponding authors, #Co-first authors)