陆青

特别研究员/长聘教轨副教授

学术经历

  • 2005-2009     南 京 大 学      学士     
  • 2009-2014   香港科技大学    博士      
  • 2014-2015   香港科技大学    博士后     
  • 2015-2016   香港科技大学    研究助理教授 
  • 2017至今      上海交通大学    特别研究员,研究组长,博士生导师

研究方向

蛋白质机器的组装与调控

本课题组将现代结构生物学、生物化学、细胞生物学技术进行有机结合,专长于蛋白质结构与生理功能相结合的科研模式,利用结构生物学方法来回答重要的生物问题。

大脑发育障碍相关的致病基因

大脑发育障碍相关的致病基因

细胞骨架及细胞骨架蛋白质动态调控机制

细胞骨架及细胞骨架蛋白质动态调控机制

遗传性耳聋相关基因

遗传性耳聋相关基因

代表论著

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    Yang X#, Wang X#, Zou Y, Zhang S, Xia M, Fu L, Vollger MR, Chen NC, Taylor DJ, Harvey WT, Logsdon GA, Meng D, Shi J, McCoy RC, Schatz MC, Li W, Eichler EE, Lu Q, Mao Y*. Characterization of large-scale genomic differences in the first complete human genome. Genome Biol. 2023 Jul 4;24(1):157.

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    Song X#, Hu R#, Chen Y#, Xiao M, Zhang H, Wu S*, Lu Q*. The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development. J Mol Cell Biol. 2024 Jan 4:mjad083.

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    Hu R, Zhou Y, Lin L, Ding B*, Lu Q*. Structure of the BLUF protein TePixD Y8F mutant. Progress in Biochemistry and Biophysics. 2023: j.pibb.2023.0095. 

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    Liu H#, Liu H#, Wang L#, Song L#, Jiang G#, Lu Q, Yang T, Peng H, Cai R, Zhao X, Zhao T, Wu H*. Cochlear transcript diversity and its role in auditory functions implied by an otoferlin short isoform. Nat Commun2023 May 29;14(1):3085.

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    Wang H#, Du H#, Ren R, Du T, Lin L, Feng Z, Zhao D, Wei X, Zhai X, Wang H, Dong T, Sun JP, Wu H, Xu Z*, Lu Q*. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation. Nat Commun2023 Mar 24;14(1):1657.

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    Mao Y, Harvey WT, Porubsky D, Munson KM, Hoekzema K, Lewis AP, Audano PA, Rozanski A, Yang X, Zhang S, Gordon DS, Wei X, Logsdon GA, Haukness M, Dishuck PC, Jeong H, Del Rosario R, Bauer VL, Fattor WT, Wilkerson GK, Lu Q, Paten B, Feng G, Sawyer SL, Warren WC, Carbone L, Eichler EE. Structurally divergent and recurrently mutated regions of primate genomes. bioRxiv [Preprint]. 2023 Mar 7:2023.03.07.531415.

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    Wang H#, Zhao D#, Du H#, Zhai X, Wu S, Lin L, Xu Z*, Lu Q*. Deafness-related protein PDZD7 forms complex with the C-terminal tail of FCHSD2. Biochem J2022 Jun 30;479(12):1393-1405.

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    Ren D#, Wei X#, Lin L#, Yuan F, Bi Y, Guo Z, Liu L, Ji L, Yang X, Han K, Yang F, Wu X, Li X, Yi Z, Xu Y, Cai C, Wang P, Li W, He L, Zhou D, Yu T, Shi Y, Lu Q*, He G*. A novel heterozygous missense variant of the ARID4A gene identified in Han Chinese families with schizophrenia-diagnosed siblings that interferes with DNA-binding activity. Mol Psychiatry2022 Jun;27(6):2777-2786.

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    Wu N, Yuan F, Yue S, Jiang F, Ren D, Liu L, Bi Y, Guo Z, Ji L, Han K, Yang X, Feng M, Su K, Yang F, Wu X, Lu Q, Li X, Wang R, Liu B, Le S*, Shi Y*, He G*. Effect of exercise and diet intervention in NAFLD and NASH via GAB2 methylation. Cell Biosci2021 Nov 4;11(1):189.

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    Zhai X, Shen Y, Zhang X, Li T, Lu Q, Xu Z*. FCHSD2 cooperates with CDC42 and N-WASP to regulate cell protrusion formation. Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119134.

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    Li J, He Y, Lu Q*, Zhang M*. Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex. Dev Cell. 2016 Jan 25;36(2):179-89.

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    Lin L#, Wang H#, Ren D#, Xia Y, He G*, Lu Q*. Structure and Membrane Targeting of the PDZD7 Harmonin Homology Domain (HHD) Associated With Hearing Loss. Front Cell Dev Biol2021 Apr 15;9:642666.

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    Li N#, Liu S#, Zhao D#, Du H, Xi Y, Wei X, Liu Q, Müller U, Lu Q*, Xiong W*, Xu Z*. Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip-link stability. PNAS. 2023 Dec.

获奖情况

  • 上海市科委扬帆人才计划入选
  • 上海高校特聘教授(东方学者)称号
  • 香港青年科学家奖

教学情况

  • 普通生物学
  • Scientific Writing and Presentation
  • 2020-2025    蛋白质机器与生命过程调控,科技部重点研发计划
  • 2019-2022    听力障碍致病基因Myosin15介导的蛋白复合物的结构与功能研究,国家自然科学基金
  • 2019-2022    上海市东方学者计划,上海市教委
  • 2018-2021    上海市扬帆计划,上海市科委
  • 2016-2019    Mechanistic Basis of Myosin 1c (Myo1c) mediated Cargo Recognition and Regulation, 香港研究资助局

承担项目

学生培养

  • 在读学生
  • 毕业学生