陆青

特别研究员/长聘教轨副教授

学术经历

  • 2005-2009     南 京 大 学      学士     
  • 2009-2014   香港科技大学    博士      
  • 2014-2015   香港科技大学    博士后     
  • 2015-2016   香港科技大学    研究助理教授 
  • 2017至今      上海交通大学    特别研究员,研究组长,博士生导师

研究方向

遗传性耳聋相关基因

遗传性耳聋相关基因

细胞骨架及细胞骨架蛋白质动态调控机制

细胞骨架及细胞骨架蛋白质动态调控机制

大脑发育障碍相关的致病基因

大脑发育障碍相关的致病基因

蛋白质机器的组装与调控

本课题组将现代结构生物学、生物化学、细胞生物学技术进行有机结合,专长于蛋白质结构与生理功能相结合的科研模式,利用结构生物学方法来回答重要的生物问题。

代表论著

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    Feng M#, Wei X#, Zheng X, Liu L, Lin L, Xia M, He G*, Shi Y*, Lu Q*. Decoding Missense Variants by Incorporating Phase Separation via Machine Learning. Nat Commun. 2024 Sep 27;15(1):8279.

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    Qiu C#, Zhang L#, Yong C, Hu R, Sun Y, Wang B, Fang L, Zhu GJ, Lu Q, Wang J*, Ma X*, Zhang L*, Wan G*. Stub1 promotes degradation of the activated Diaph3: A negative feedback regulatory mechanism of the actin nucleator. J Biol Chem. 2024 Oct;300(10):107813.

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    Dai Y, Idorn M, Serrero MC, Pan X, Thomsen EA, Narita R, Maimaitili M, Qian X, Iversen MB, Reinert LS, Flygaard RK, Chen M, Ding X, Zhang BC, Carter-Timofte ME, Lu Q, Jiang Z, Zhong Y, Zhang S, Da L, Zhu J, Denham M, Nissen P, Mogensen TH, Mikkelsen JG, Zhang SY, Casanova JL, Cai Y*, Paludan SR*. TMEFF1 is a neuron-specific restriction factor for herpes simplex virus. Nature. 2024 Aug;632(8024):383-389.

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    Ruan K, Bai G, Fang Y, Li D, Li T, Liu X, Lu B, Lu Q, Songyang Z, Sun S, Wang Z, Zhang X, Zhou W, Zhang H. Biomolecular condensates and disease pathogenesis. Sci China Life Sci. 2024 Sep;67(9):1792-1832.

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    Cao Y#, Tian GG#, Hong X, Lu Q, Wei T*, Chen HF*, Wu J*. Reproductive chemical database: a curated database of chemicals that modulate protein targets regulating important reproductive biological processes. Cell Biosci. 2024 Jun 6;14(1):73.

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    Mao Y*, Harvey WT, Porubsky D, Munson KM, Hoekzema K, Lewis AP, Audano PA, Rozanski A, Yang X, Zhang S, Yoo D, Gordon DS, Fair T, Wei X, Logsdon GA, Haukness M, Dishuck PC, Jeong H, Del Rosario R, Bauer VL, Fattor WT, Wilkerson GK, Mao Y, Shi Y, Sun Q, Lu Q, Paten B, Bakken TE, Pollen AA, Feng G, Sawyer SL, Warren WC, Carbone L, Eichler EE*. Structurally divergent and recurrently mutated regions of primate genomes. Cell. 2024 Mar 14;187(6):1547-1562.e13.

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    Li N#, Liu S#, Zhao D#, Du H, Xi Y, Wei X, Liu Q, Müller U, Lu Q*, Xiong W*, Xu Z*. Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip-link stability. Proc Natl Acad Sci U S A. 2024 Mar 5;121(10):e2309656121.

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    Song X#, Hu R#, Chen Y#, Xiao M, Zhang H, Wu S*, Lu Q*. The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development. J Mol Cell Biol. 2024 Jul 1;16(1):mjad083.

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    Yang X#, Wang X#, Zou Y, Zhang S, Xia M, Fu L, Vollger MR, Chen NC, Taylor DJ, Harvey WT, Logsdon GA, Meng D, Shi J, McCoy RC, Schatz MC, Li W, Eichler EE, Lu Q, Mao Y. Characterization of large-scale genomic differences in the first complete human genome. Genome Biol. 2023 Jul 4;24(1):157.

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    Wang H#, Du H#, Ren R, Du T, Lin L, Feng Z, Zhao D, Wei X, Zhai X, Wang H, Dong T, Sun JP, Wu H, Xu Z*, Lu Q*. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation. Nat Commun. 2023 Mar 24;14(1):1657.

获奖情况

  • 上海市科委扬帆人才计划入选
  • 上海高校特聘教授(东方学者)称号
  • 香港青年科学家奖

教学情况

  • 普通生物学
  • Scientific Writing and Presentation
  • 2020-2025    蛋白质机器与生命过程调控,科技部重点研发计划
  • 2019-2022    听力障碍致病基因Myosin15介导的蛋白复合物的结构与功能研究,国家自然科学基金
  • 2019-2022    上海市东方学者计划,上海市教委
  • 2018-2021    上海市扬帆计划,上海市科委
  • 2016-2019    Mechanistic Basis of Myosin 1c (Myo1c) mediated Cargo Recognition and Regulation, 香港研究资助局

承担项目

学生培养

  • 在读学生
  • 毕业学生